Objective To retrospectively study the original lesion resection for the treatment of secondary epilepsy with ECoG monitoring daring operations and discuss the value of intraoperative ECoG monitoring. Methods By means of observing the treatment of 62 patients with secondary epilepsy, we analyzed the significance of intraoperative ECoG monitoring in the treatment of secondary epilepsy with the original lesion resection and peripheral cortices fulguration of low energy. Among the 62 cases, 15 patients were meningiomas,18 were gliomas,15 were cavernous hemangiomas,5 were arachnoid cysts, 5 were post-traumatic changes,2 were epidermoid cysts and 2 were arteriovenous malformations. Results There was no epileptic wave in all patients with regular postoperative EEG. 62 patients were survived from the operations without newly occurred malfunction. A follow-up investigation lasting from 10 months to 3 years revealed that there was no epilepsy recurrence in all the patients except for partial epilepsy recurrence in two patients. But their recurrence frequency reduced for about 90% and the epilepsy recurrence was not found in these two patients after the treatment with antiepileptic drugs.Conclusion In the treatment of intracranial occupying lesions accompanied with secondary epilepsy, the monitoring of ECoG during surgery is necessary for the guidance of the original lesion resection.