Clinical Original Article
Effect of gonadotropin-releasing hormone analogue treatment on body mass index in central precocious puberty or early and fast puberty girls
Qiuli Chen, Zhe Su, Yanhong Li, Huamei Ma, Hongshan Chen, Jun Zhang, Yufen Gu, Minlian Du
Published 2015-08-25
Cite as Chin J Endocrinol Metab, 2015, 31(8): 690-695. DOI: 10.3760/cma.j.issn.1000-6699.2015.08.008
Abstract
ObjectiveTo study the effect on body mass index(BMI)caused by treatment with Gonadotropin-releasing hormone analogs(GnRHa)in girls with central precocious puberty(CPP)or early and fast puberty(EFP).
MethodsThe BMI in 318 girls(227 CPP and 91 EFP)treated with GnRHa alone was analyzed. Among them 89 were followed up to their final adult height.
ResultsBefore GnRHa treatment was started, the girls with CPP and EFP had a mean BMI standard deviation score(SDS)for chronological age(BMISDSCA)of 0.39±0.84 and for bone age(BMISDSBA)of -0.11±0.69. At the end of treatment, the mean BMISDSCA was 0.59±1.01 and BMISDSBA was 0.24±0.89, both were significantly higher than those at initiation. The increment in BMISDSBA(0.38±0.50)was greater than that in BMISDSCA(0.21±0.56). Moreover, the ratio of overweight(BMI>85%)was significantly elevated. BMISDSCA of 89 girls who were visited at their final adult height was 0.17±1.15, which was similar with BMISDS at initiation and in normal population.
ConclusionThe mean BMISDSCA of CPP and EFP was significantly higher than the general population, while BMISDSBA was significantly lower. During GnRHa treatment, BMISDS tended to be elevated. But it was reversible, for the mean BMISDS was back to normal at final adult height. (Chin J Endocrinol Metab, 2015, 31: 690-695)
Key words:
Central precocious puberty; Early and fast puberty; Gonadotropin-releasing hormone analogs; Body mass index
Contributor Information
Qiuli Chen
Department of Pediatrics, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
Zhe Su
Yanhong Li
Huamei Ma
Hongshan Chen
Jun Zhang
Yufen Gu
Minlian Du
