To study the characteristic of HLA distribution of Chinese Bone Marrow Bank (Shanghai), this paper analyses the HLA distribution of a population of 11 995 persons which were major part of this Bank.

HLA-A、B antigen of volunteers were detected by MLT (microlympho-cytetotoxicity test) method, and at the same time, some samples were selected as control and their AB locus were typed at the DNA level by PCR-SSP method, ambiguous samples were checked by PCR-SSO also.

HLA-A、B typing results of 11 995 volunteers were gotten, and their antigen frequency, gene frequency, haplotype frequency and linkage disequilibrium parameter were gotten also.

the HLA-A、B distribution of this population its own characters, according to these characters, we can induce Chines Bone Marrow Bank (Shanghai) were mainly between the south and the north han-population, a little closer to the northern. There are gotten more than 60 binds haplotypes which had significant linkage disequilibrium sense, among them, the most common were A2-B46, A30-B13, A33-B58, A11.1-B60, A24-B62, A24-B60. And the chance of finding out a matched donor from this Bank is roughly one-thousandth.

Bone marrow; Biological specimen banks; HLA antigens; Gene frequency; Data collection