Clinical Study
Epidemiological investigation on the prevalence of anemia and the standard-reaching rate of hemoglobin in patients with maintenance hemodialysis in Anhui province
Lei Ye, Guixia Zhang, Yangyang Huang, Guangrong Qian, Weidong Chen, Chengfu Wang, Jiuhuai Han, Bin Hu, Zhi Liu, Runzhi Shui, Ligang Liu, Xiuyong Li, Guangcai Shi, Wei Wang, Youwei Bai, Shengyin Ma, Jianghuai Zhang, Peng Han, Huaiqing Wang, Jiande Chen, Bin Hu, Bengui Sun, Liping Ye, Suhang Wang, Jinru Wang, Kaipeng Li, Lei Chen, Li Hao, Deguang Wang
Published 2016-04-15
Cite as Chin J Nephrol, 2016, 32(4): 264-270. DOI: 10.3760/cma.j.issn.1001-7097.2016.04.005
Abstract
ObjectiveTo explore the prevalence of anemia, percentage of patients with hemoglobin (Hb) reaching the guideline target, and its impact factors in maintenance hemodialysis (MHD) patients in Anhui province.
MethodsTwo thousand six hundred and one cases of MHD patients were investigated in hemodialysis centers of 26 hospitals in southern, northern and central Anhui province from January 1st, 2014 to March 31st, 2014. Age, gender and clinical information on renal disease history, duration of dialysis therapy, types of dialysis, medical history, and laboratory results, were collected. The prevalence of anemia, percentage of patients with Hb levels reaching the guideline target (Hb≥110 g/L) and the associated factors of Hb were analyzed.
Results(1) Mean Hb concentration was (100.2±28.1) g/L, 82.5% of patients were diagnosed as anemia. The use rate of erythropoietin, intravenous iron and folic acid were 95.2%, 64.3% and 62.0% respectively. (2) Hb≥110 g/L rate was 32.8%. The percentage of patients with Hb≥110 g/L was higher in males than that in females (35.1% vs 29.4%, P=0.002). Patients with high flux dialysis had a higher percentage of Hb≥110 g/L than those with low flux dialysis (39.2% vs 27.9%, P<0.001). (3) Compared with patients whose Hb≥110 g/L, patients with <110 g/L had shorter duration of dialysis therapy, lower albumin, creatinine, triglyceride, calcium, phosphorus, magnesium, and higher hs-CRP, higher usage rates of erythropoietin, intravenous iron and folic acid (all P<0.05). (4) The 2.10-2.50 mmol/L calcium (OR=0.346, P=0.005), >2.50 mmol/L calcium (OR=0.207, P=0.001), >41.9 g/L albumin (OR=0.511, P=0.044), 1.11-2.01 mmol/L triglyceride (OR=0.443, P=0.008), >2.01 mmol/L triglyceride (OR=0.257, P<0.001) and ≥7.63 mg/L hs-CRP (OR=1.652, P=0.049) were influence factors causing Hb to fall below.
ConclusionsThere are high prevalence of anemia and low control rate of hemoglobin in MHD patients in Anhui province. Normal-calcium, hypercalcemia, higher albumin and triglyceride are protective factors of Hb target, but higher hs-CRP is its independent risk factors. The rational use of erythropoietin and intravenous iron, high flux dialysis, well nutrition states, correcting of the hypocalcemia and inflammatory state may contribute to improving the hemoglobin levels.
Key words:
Renal dialysis; Anemia; Hemoglobins
Contributor Information
Lei Ye
Nephrology Department, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China
Guixia Zhang
Yangyang Huang
Guangrong Qian
Weidong Chen
Chengfu Wang
Jiuhuai Han
Bin Hu
Zhi Liu
Runzhi Shui
Ligang Liu
Xiuyong Li
Guangcai Shi
Wei Wang
Youwei Bai
Shengyin Ma
Jianghuai Zhang
Peng Han
Huaiqing Wang
Jiande Chen
Bin Hu
Bengui Sun
Liping Ye
Suhang Wang
Jinru Wang
Kaipeng Li
Lei Chen
Li Hao
Deguang Wang
