Original Article
Sebaceoma: a clinicopathological analysis of 31 cases
Lixiong Gu, Dezhi Zhang, Xiaoyan Wu, Xuebao Shao, Amei Li, Shengju Yang, Shuanglin Cao, Xiaodong Chen, Hao Chen
Published 2016-08-15
Cite as Chin J Dermatol, 2016, 49(8): 555-557. DOI: 10.3760/cma.j.issn.0412-4030.2016.08.007
Abstract
ObjectiveTo analyze clinicopathologic features of sebaceoma.
MethodsClinical, pathologic and immunohistochemical findings from 31 cases of sebaceoma were retrospectively analyzed. The clinicopathologic features of sebaceoma were investigated.
ResultsThere were 9 males and 22 females. The patients′ age was 53.90 ± 15.40 years, and the clinical course was 9.41 ± 13.75 years. Sebaceoma predominantly affected the face. The common lesion of sebaceoma was red, yellowish-red, skin-colored or slight brown papules, with no subjective symptoms in most cases. Histopathologically, neoplasms had symmetric structures, and were located in the dermis. Epidermal involvements were found in 9 cases. The neoplasm cells were mainly composed of basaloid cells, a few mature sebocytes and some transition cells. The proportion of mature sebocyts was less than 1% in 26 cases, less than 20% in 2 cases, and 20%-40% in 3 cases. Mitoses were occasionally found in 5 cases. One patient was complicated by eccrine poroma. Varying amounts of ducts were found in all the patients. Immunohistochemical staining showed that epithelial membrane antigen was expressed on ducts and mature sebocytes in all the patients, while epithelial antigen was undetected in any of the patients. Carcinoembryonic antigen, androgen receptor and D2-40 were found in 20, 24 and 28 patients with sebaceoma, respectively.
ConclusionsThe diagnosis of sebaceoma mainly depends on histopathological examination. Combined immunohistochemical detection of epithelial membrane antigen, androgen receptor and D2-40 is beneficial to its differential diagnosis.
Key words:
Sebaceoma; Carcinoembryonic antigen; Receptors, androgen; Epithelial membrane antigen; Epithelial antigen; D2-40
Contributor Information
Lixiong Gu
Department of Dermatology and Venerology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China
Dezhi Zhang
Department of Dermatology, People′s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
Xiaoyan Wu
Department of Dermatology and Venerology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China
Xuebao Shao
Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
Amei Li
Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
Shengju Yang
Department of Dermatology and Venerology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China
Shuanglin Cao
Department of Dermatology and Venerology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China
Xiaodong Chen
Department of Dermatology and Venerology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China
Hao Chen
Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
