HAART can successfully reduce HIV replication, so as to prolong survival period and reduce mortality. However, HAART cannot cure HIV because of the long-living HIV-1 reservoirs. In this article, the definition of HIV reservoirs and reservoir detection methods are introduced, and the possible elimination methods including IFN combined HAART treatment, "shock and kill" treatment, kill of persisting HIV infected cells by immunotherapy and gene editioring to induce antibody in target cells are summarized. These elimination strategies can provide a reference basis for achieving the goal for curing HIV.

HIV-1; Viral reservoirs; CD4⁺T cells; Gene editing