Review Article•Pain Clinic
Advance in the rostral ventromedial medulla involving descending inhibitory/facilitatory system
Wei Wang, Jing Xu, Yanjie Wan
Published 2016-09-15
Cite as Int J Anesth Resus, 2016, 37(9): 852-855,864. DOI: 10.3760/cma.j.issn.1673-4378.2016.09.020
Abstract
BackgroundIn the process of pain, the endogenous descending inhibitory system was found to play an important role in pain transmission and modulation. Later, as people continue to study, the descending facilitatory system is proved to be different from the descending inhibitory system.
ObjectiveTo further summarize the mechanism of the descending inhibitory/facilitatory system of rostral ventromedial medulla(RVM).
ContentThe brain is modulated by peripheral nociceptive information through descending inhibitory/facilitatory system. The RVM is a set of critical nuclei in the pathway of the descending inhibitory and facilitatory. RVM produce inhibited or excited effects as a response to drug or electrical stimulation, which involved in the activation of the descending inhibitory/facilitatory system.
TendRVM needs to be further studied on how to participate in the regulation of nociceptive stimulus information in the descending inhibitory and facilitatory system.
Key words:
Rostral ventromedial medulla; The descending inhibitory system; The descending facilitatory system; Pain; Cerebral aqueduct
Contributor Information
Wei Wang
Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, China
Jing Xu
Department of Pain, Shanghai Pudong New Area Gongli Hospital, Shanghai 200135, China
Yanjie Wan
Department of Pain, Shanghai Pudong New Area Gongli Hospital, Shanghai 200135, China
