Clinical Epidemiology
Effect of gender on the prognosis of patients with non-small cell lung cancer
Qiuping Xu, Fei He, Zhiqiang Liu, Weimin Xiong, Jianbo Lin, Lin Cai
Published 2017-02-10
Cite as Chin J Epidemiol, 2017, 38(2): 244-247. DOI: 10.3760/cma.j.issn.0254-6450.2017.02.022
Abstract
ObjectiveTo analyze the effect of gender on the prognosis of patients with non-small cell lung cancer (NSCLC).
MethodsData of 1 195 patients with NSCLC were analyzed by Chi-square, Kaplan-Meier, log-rank tests and Cox regression models.
ResultsWomen had a longer survival than men (median overall survival 31.64 versus 22.71 months, P<0.01) in the participants of this study. Differences seen in overall survival remained the similar, after stratified by age, pathologic types, clinical stage, sizes, pleural effusion and surgery of the patients, respectively. Data from the multivariate analysis revealed that factors as smoking, clinical stage, metastatic when diagnosis was made and surgery, but not gender, were independent prognostic factors for patients with NSCLC. After adjustment for potential confounders, we found that smoking was a major confounding factor, affecting the relationship between gender and prognosis of NSCLC.
ConclusionGender did not seem an independent prognostic factor for NSCLC patients while the survival advantages of females might be attributed to the lower prevalence of smoking in this population.
Key words:
Non-small cell lung cancer; Prognosis; Sex
Contributor Information
Qiuping Xu
Department of Epidemiology and Health Statistics, The First Affiliated Hospital Fujian Medical University, Fuzhou 350108, China
Fei He
Department of Epidemiology and Health Statistics, The First Affiliated Hospital Fujian Medical University, Fuzhou 350108, China
Zhiqiang Liu
Department of Epidemiology and Health Statistics, The First Affiliated Hospital Fujian Medical University, Fuzhou 350108, China
Weimin Xiong
Department of Epidemiology and Health Statistics, The First Affiliated Hospital Fujian Medical University, Fuzhou 350108, China
Jianbo Lin
School of Public Health, Department of Chest Surgery, The First Affiliated Hospital Fujian Medical University, Fuzhou 350108, China
Lin Cai
Department of Epidemiology and Health Statistics, The First Affiliated Hospital Fujian Medical University, Fuzhou 350108, China
