Breast Radiology
Diagnostic performance of contrast-enhanced spectral mammography
Tingting Jiang, Shengjian Zhang, Ruimin Li, Jian Wu, Yajia Gu, Weijun Peng
Published 2017-04-10
Cite as Chin J Radiol, 2017, 51(4): 273-278. DOI: 10.3760/cma.j.issn.1005-1201.2017.04.008
Abstract
ObjectiveTo assess the value of contrast enhanced mammography (CESM) in the detection of breast cancer.
MethodsA total of 145 patients who were suspected of breast abnormalities by clinical examination or ultrasound were prospectively collected. All patients underwent bilateral breast CESM and MRI examinations. Breast CESM and MRI examination were completed in the same week. The pathological specimens were analyzed and the maximum diameters of pathological lesions were measured. The lesions were observed on low energy(LE), CESM and MRI images, and then the maximum diameters of lesions on the above images were measured. Using pathology results as the gold standard, the diagnostic efficacy of LE, CESM and MRI were analyzed by ROC curve, and Z test was used to compare the areas under the ROC curves among different imaging methods. Bland-Altman method was used to analyze the consistency of the maximum diameters of the lesions obtained with different imaging methods.
ResultsOne hundred and fifty three lesions were found in 145 patients, in which 36 were benign and 117 were malignant. The LE, CESM and MRI showed 140, 151 and 149 lesions respectively, and the qualitative diagnostic errors were 25, 8 and 11, respectively. The areas under ROC curves of LE, CESM and MRI were 0.87, 0.96 and 0.97 respectively. There was significant difference of the area under ROC curve between CESM and LE, so did the MRI and LE (P<0.05), but there was not significant difference between CESM and MRI (P=0.51). The sensitivity, specificity and accuracy in the diagnosis of malignant breast lesions were 88.98%, 65.71% and 83.66% for LE, while they were 95.80%, 91.18% and 94.77% for CESM, 94.17%, 87.88% and 92.81% for MRI. The average difference of diameters between LE, CESM, MRI and pathologic size was -1.7, 1.1 and 0.3 mm, respectively, with 95% consistency interval range of -18.6 to 15.1,-9.8 to 12.1,-10.6 to 11.2 mm, respectively. There was best consistency between the pathological size and the size on MRI.
ConclusionCESM can significantly improve the diagnostic efficacy of breast lesions, which is comparable with MRI.
Key words:
Breast neoplasms; Magnetic resonance imaging; Contrast-enhanced spectral mammography
Contributor Information
Tingting Jiang
Department of Radiology, Fudan University Cancer Hospital, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Shengjian Zhang
Ruimin Li
Jian Wu
Yajia Gu
Weijun Peng
