[Objective] To analyze the reasons of unplanned extubation(UE)of deep venous catheter (DVC)and explore the prevention strategies.[Methods] The experiences and lessons of maintenance of deep venous catheter of 410 patients were retrospectively reviewed,causes of unplanned extubation in 25 cases were analyzed.[Results] Catheter obstruction,accidental pulling-off of eatheter,catheter-related infections,thrombosis formation,skin allergy and other complications were the main reasons for unplanned extubation.These complications were mainly related to patients,medical staff factors and catheter sites or other relevant situations.[Conclusions] The measures such as fully understanding and correct analysis of unplanned extubation reasons,assessment of risk factors,actively seeking effective nursing intervention measures to ensure the standardization of the nursing practice can significantly reduce the rate of unplanned extubation.