Original Article
Influencing factors and outcome of cholestasis in preterm infants
Ding Ruiwei, Li Juan
Published 2021-06-26
Cite as Int J Pediatr, 2021, 48(6): 414-419. DOI: 10.3760/cma.j.issn.1673-4408.2021.06.012
Abstract
ObjectiveTo investigate the clinical features, influencing factors and outcome of cholestasis in preterm infants.
MethodsThe clinical data of premature infants(case group)admitted to the Neonatal Department of Shengjing Hospital of China Medical University and diagnosed with cholestasis from January 2016 to December 2018 were analyzed retrospectively.Non-cholestatic preterm infants who were hospitalized at the same time, with the same number, gestational age and birth weight were selected as the control group.The clinical data of the two groups were compared to understand the clinical features and risk factors of premature infant cholestasis, and to explore its influence on the development of premature infants.
ResultsThe total cases were 112(the ratio of male to female is 2.02). The gestational age ranged from 25 to 36 weeks, the median gestational age(interquartile interval)was 30(28, 31)weeks, and the gestational age <32 weeks accounted for 78%.The birth weight was 440 to 3 840 g, the median birth weight(interquartile interval)was 1 142(979, 1 300)g, and the birth weight <1 500 g accounted for 83%.The duration of parenteral nutrition, hospital stay, beginning enteral feeding, and reaching total enteral feeding in the case group were 37 d, 62 d, 5 d, and 37 d, respectively, while those in the control group were 23 d, 45 d, 4 d, and 22 d, respectively, with statistical significance( P<0.05). The incidence of necrotizing enterocolitis, patent ductus arteriosus and extrauterine growth retardation in the case group was 16.1%, 15.2% and 91.2%, respectively, while the incidence of corresponding diseases in the control group was 4.5%, 6.1% and 83%, with statistical significance between the two groups(P<0.05). The rate of weight gain after cholestasis was 8 g/(kg·d)in the case group and 13 g/(kg·d)in the control group, and the difference between the two groups was statistically significant(P<0.05). Logistic regression analysis showed that prolonged parenteral nutrition was an independent risk factor for cholestasis in preterm infants.
ConclusionCholestasis in preterm infants is more common in ultrafast preterm infants and early preterm infants or in infants with extremly low or very low birth weight.The incidence of was increased with cholestasis, and the length of hospital stay was prolonged.Prolonged parenteral nutrition is an independent risk factor for cholestasis in preterm infants.
Key words:
Premature infants; Cholestasis; Parenteral nutrition; Malnutrition
Contributor Information
Ding Ruiwei
The Neonatal Department, Shengjing Hospital of China Medical University, Shenyang 110004, China
Li Juan
The Neonatal Department, Shengjing Hospital of China Medical University, Shenyang 110004, China
