The research progress on the nursing intervention of deep vein thrombosis of lower limb was summarized in this article,it included risk factors assessment of high-risk population,some presently common mechanical auxiliary way,venous protection,diet guidance,drug prevention and lower extremity blood circulation assessment etc.In order to strengthen the internal high-risk patients with lower extremity venous thrombosis prevention,primary screening evaluation process was should be carried out at first,according to the risk factors of thrombosis in high-risk patients,systematic and comprehensive nursing intervention measures were brought forward.The development trend of mechanical prevention nursing intervention and the concrete implementation were stated to provide the reference for clinical nurses.