T follicular helper cells(Tfh) are the recently defined CD4 + T helper subtype, whose function is to provide help for the B cell antibody production. The development, differentiation and function of follicular helper T cells is differrent from the previous Th1, Th2 and Th17 subsets. Tfh cells play a key role in humoral immunoresponses. Tfh cella also contribute to the production of long living plasma cells. The coordination between the transcription factor, Bcl-6 and Blimp-1, can regulate the expression of chemokine receptors,surface molecules and cytokines of Tfh cells.