Original Article
Relationship between natural killer cells, CD3 cells and disease progression in patients with early psoriatic arthritis
Hong Tao, Guangman Wang, Jianguo Zheng, Qing Ye, Kun Fu, Xiaoyan Cao, Xiaoli Cheng
Published 2019-05-05
Cite as Int J Immunol, 2019, 42(3): 285-289. DOI: 10.3760/cma.j.issn.1673-4394.2019.03.011
Abstract
ObjectiveTo investigate the relationship between natural killer (NK) cells, CD3 cells, and the progression of psoriatic arthritis.
Methods72 patients with psoriatic arthritis in Hubei University of Medicine were recruited as subjects for this study.72 health individuals in the same hospital taking physical examination were recruited as controls.Natural killer (NK) cells and CD3 cells were determined by flow cytometry.The poriasis area and severity index(PASI) scores were used to evaluate disease progression.
ResultsCompared with the control group , the proportion of NK cells[(14.59±3.14)% vs.(10.49±4.11)%] and CD3 cells[(33.94±6.13)% vs.(18.44±5.29)%]of the patients were obviously reduced(t values were 6.393 and 11.832 respectively, both P<0.05). The psoriasis area and severity index (PASI) score of the patients were significantly higher than that of controls[(43.11±5.39)vs.(11.39±5.01), t=14.592, P<0.05]. There was a negative correlation between the proportion of NK cells, CD16 cells and the PASI score for patients(r=-0.409, -0.382, P<0.05).
ConclusionPatients at the early stage of psoriatic arthritis more likely have low levels of NK and CD3 cells, which are correlated with the progression of the disease.
Key words:
Psoriatic arthritis; Natural killer cells; CD3 cells
Contributor Information
Hong Tao
Department of Rheumatology and Immunology, Renmin Hospital , Hubei University of Medicine, Shiyan Hubei 442000, China
Guangman Wang
Institute of Medicine and Nursing , Hubei University of Medicine(College of Nursing), Shiyan Hubei 442000, China
Jianguo Zheng
Department of Rheumatology and Immunology, Renmin Hospital , Hubei University of Medicine, Shiyan Hubei 442000, China
Qing Ye
Department of Rheumatology and Immunology, Renmin Hospital , Hubei University of Medicine, Shiyan Hubei 442000, China
Kun Fu
Department of Rheumatology and Immunology, Renmin Hospital , Hubei University of Medicine, Shiyan Hubei 442000, China
Xiaoyan Cao
Department of Rheumatology and Immunology, Renmin Hospital , Hubei University of Medicine, Shiyan Hubei 442000, China
Xiaoli Cheng
Department of Rheumatology and Immunology, Renmin Hospital , Hubei University of Medicine, Shiyan Hubei 442000, China
