Original Article
Expression and significance of HLA-A and CD8 in cervical cancer
Gao Minghui, Chen Kaili, Liu Xinyu, Dong Shuhong, Hu Yanan, Hu Chunjie
Published 2022-04-15
Cite as Int J Genet, 2022, 45(2): 83-90. DOI: 10.3760/cma.j.cn231536-20211129-00143
Abstract
ObjectiveTo investigate the expression and significance of HLA-A and CD8 in cervical cancer tissues.
MethodsImmunohistochemical was used to detect the expression of HLA-A and CD8 in normal cervical tissue, high-grade squamous intraepithelial disease (HSIL) and cervical cancer, and to analyze their relationship with cervical cancer and their significance.
ResultsThe expression of HLA-A in normal cervical tissue, HSIL and cervical cancer tissue was statistically different(P=0.004). The expression of HLA-A in cervical cancer tissues was correlated with clinical stage, pathological grade and lymphatic metastasis.The expression of CD8 in normal cervical tissue, HSIL and cervical cancer was statistically different(P=0.002). The expression of CD8 in cervical cancer tissues was correlated with clinical stage, pathological grade and lymphatic metastasis.There was a positive correlation between HLA-A and CD8 expression in cervical cancer(r=0.314).
ConclusionHLA-A and CD8 play an important role in the occurrence and development of cervical cancer, and HLA-A has a positive correlation with CD8 expression in cervical cancer.
Key words:
HLA-A; CD8; Cervical cancer; Immunohistochemical
Contributor Information
Gao Minghui
Department of Gynecology and Obstetrics, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China
Chen Kaili
Department of Gynecology and Obstetrics, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China
Liu Xinyu
Department of Gynecology and Obstetrics, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China
Dong Shuhong
Department of Gynecology and Obstetrics, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China
Hu Yanan
Department of Gynecology and Obstetrics, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China
Hu Chunjie
Department of Gynecology and Obstetrics, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China
