Clinical Original Article
Accuracy and clinical application of a REF-XT01 uric acid meter
Li Maichao, He Yuwei, Li Hailong, Lu Jie, Zhang Jie, Wang Xuefeng, Ren Wei, Wang Can, Pang Lei, Wang Ming, Li Changgui, Ji Xiaopeng
Published 2020-11-25
Cite as Chin J Endocrinol Metab, 2020, 36(11): 932-937. DOI: 10.3760/cma.j.cn311282-20191206-00538
Abstract
ObjectiveThis study aimed to evaluate the accuracy of a portable REF-XT01 uric acid meter in measuring blood uric acid concentration, and to determine whether the results of the uric acid meter could be used to guide the adjustment of uric acid-lowering drugs.
Methods1 551 subjects were enrolled from the Gout Clinical Medical Center of the Affiliated Hospital of Qingdao University. The fasting venous blood was collected and the serum uric acid was measured by an automatic biochemical analyzer. Meanwhile, the capillary blood uric acid was measured by fingertip puncture using the REF-XT01 uric acid meter. Linear regression, intra-group correlation coefficient(ICC), and Bland-Altman plots were used to analyze the uric acid concentration correlation between the biochemical analyzer(sUABA)and the uric acid meter(sUAUM). The receiver operating characteristic curve(ROC curve)was conducted to evaluate whether sUAUM can be used as a reference for the gout patients to take uric acid-lowering drugs.
ResultsThe regression analysis showed correlation between sUABA and sUAUM, with the regression formula Y=0.875X+ 39.525(r=0.84, P<0.01)and the ICC was 0.829(95%CI 0.814-0.844, P<0.01). The Bland-Altman diagram showed a good consistence(the absolute deviation was-143.4-114.5 μmol/L, mean deviation was -14.4 μmol/L)between sUABA and sUAUM. The sensitivity was 96.61%, specificity was 48.81%, and the area under the ROC curve(AUC)was 0.926(P<0.01)when 300 μmol/L was defined as the detection threshold of the uric acid meter, the sensitivity was 90.98%, specificity was 66.78%, and the area under the ROC curve(AUC)was 0.914(P<0.01)when 360 μmol/L was defined as the detection threshold of the uric acid meter.
ConclusionREF-XT01 uric acid meter is applicable for the adjustment of uric acid-lowering drugs for the gout patients, because of its high accuracy for the detection of uric acid.
Key words:
Uric acid meter; Gout; Uric acid-lowering drugs
Contributor Information
Li Maichao
Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
He Yuwei
Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
Li Hailong
Institute of Metabolic Diseases, Qingdao University, Qingdao 266003, China
Lu Jie
Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
Zhang Jie
Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
Wang Xuefeng
Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
Ren Wei
Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
Wang Can
Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
Pang Lei
Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
Wang Ming
Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
Li Changgui
Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
Ji Xiaopeng
Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao 266003, China
