Clinical Original Article
Study on the relationship between sex hormone and lipid metabolism in overweight and obese boys aged 9 to 12 years
Cao Yuping, Liang Chunyu, Yan Yi
Published 2021-03-25
Cite as Chin J Endocrinol Metab, 2021, 37(3): 212-220. DOI: 10.3760/cma.j.cn311282-20210114-00034
Abstract
ObjectiveTo explore the specific changes and correlations of sex hormones and lipid metabolism in overweight and obese boys aged 9-12 years.
MethodsSeventy-two male subjects (9 to 12 years old) were divided into normal weight group (n=42), overweight group (n=15), and obese group (n=15). Plasma sex hormone levels and lipid levels were detected by chemiluminescence immunoassay and ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC/QTOF/MS). All data were analyzed by multivariate statistics analysis.
Results(1) The serum concentration of sex hormone-binding globulin (SHBG) in obese group and overweight group was significantly lower than that in normal weight group, and the serum concentration of SHBG in obese group was significantly lower than that in overweight group (P<0.05). The serum concentrations of dehydroepiandrosterone (DHEA) in overweight and obese group were significantly higher than those in normal weight group (P<0.05). (2) There were 171 kinds of differential lipid compounds between normal weight group and overweight group, 218 species of differential lipid compounds between normal weight group and obese group, and 34 species of differential lipid compounds between overweight and obese group. Among them, 150 kinds of lipid compounds in normal weight group were significantly different from those in overweight and obese group. (3) SHGB was positively correlated with phosphatidyl cholines (PC) (20∶0/0∶0) and PC[18∶1(9E)/0∶0](r=0.6, P<0.05), DHEA was positively correlated with diacylglycerol (DG)[17∶2(9Z, 12Z)/22∶0/0∶0](r=0.5, P<0.05).
Conclusions9-12 years old overweight and obese boys had early growth and development, but sex hormone levels were not synchronized with growth and development. The serum DHEA level in overweight and obese boys was significantly increased, while the level of DG [17∶2 (9Z, 12Z)/22∶0/0∶0] was significantly increased, and the serum SHGB concentration was significantly decreased, while the vast majority of PC was significantly down-regulated. The mechanism of these changes needs to be further studied.
Key words:
Lipoproteomics; Sex hormones; Obesity; Overweight; Children
Contributor Information
Cao Yuping
Beijing Sport University, Beijing 100084, ChinaCao Yuping is working on the Xinjiang Normal University, Urumqi530054, China
Cao Yuping is working on the Xinjiang Normal University, Urumqi530054, China
Liang Chunyu
Beijing Sport University, Beijing 100084, ChinaCao Yuping is working on the Xinjiang Normal University, Urumqi530054, China
Yan Yi
Beijing Sport University, Beijing 100084, ChinaCao Yuping is working on the Xinjiang Normal University, Urumqi530054, China
