Clinical Original Article
Correlation analysis between serum uric acid and clinical features of patients with novel coronavirus pneumonia
Xu Zhouwei, Chen Xiaohua, Wang Peng, Zhao Yuwu, Fan Xiaohong
Published 2021-07-25
Cite as Chin J Endocrinol Metab, 2021, 37(7): 631-636. DOI: 10.3760/cma.j.cn311282-20201022-00700
Abstract
ObjectiveTo analyze the correlation between serum uric acid and clinical features of patients with novel coronavirus pneumonia(COVID-19).
MethodsA total of 200 patients with COVID-19 admitted to Wuhan Lei Shen Shan hospital from January 20, 2020 to April 10, 2020 were included in this retrospective cohort study. The patients were divided into the hyperuricemia group and the non-hyperuricemia group. The data of patients were collected through electronic medical record system. SPSS 19.0 and Graphpad Prism 8.0 statistical software were used to compare clinical features, laboratory results, survival time, and prognosis of patients between hyperuricemia and non-hyperuricemia groups.
ResultsCompared with the non-hyperuricemia group, the hyperuricemia group showed a higher BMI and mortality(P<0.05)as well as higher white blood cell count, lymphocytes, serum creatinine, creatine kinase, cystatin C, myoglobin, interleukin(IL)-6 levels(P<0.05). Serum uric acid level was positively correlated with lymphocytes, hemoglobin, albumin, creatinine, creatine kinase, cystatin C, D-dimer levels while negatively correlated with IL-2 receptor and IL-8. The patients with hyperuricemia had significantly shorter survival time and worse prognosis than those without hyperuricemia(P=0.04).
ConclusionCOVID-19 patients with hyperuricemia show higher mortality and worse prognosis compared with the patients with non-hyperuricemia.
Key words:
Novel coronavirus pneumonia; Hyperuricemia; Clinical features; Prognosis; Risk factors
Contributor Information
Xu Zhouwei
Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital, Shanghai 200233, China
Chen Xiaohua
Department of Infectious Disease, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital, Shanghai 200233, China
Wang Peng
Department of Infectious Disease, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital, Shanghai 200233, China
Zhao Yuwu
Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital, Shanghai 200233, China
Fan Xiaohong
Department of Respiratory Medicine, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital, Shanghai 200233, China
