Clinical Original Article
Spermatogenesis of combined HCG and HMG in patients with idiopathic hypogonadotropic hypogonadism and congenital combined pituitary hormone deficiency
Wang Weijie, Shao Mingwei, Chen Yuansi, Fan Yaya, Lian Mengqing, Wang Shanshan, Wang Xiaotong, Qin Guijun
Published 2022-07-25
Cite as Chin J Endocrinol Metab, 2022, 38(7): 601-607. DOI: 10.3760/cma.j.cn311282-20211021-00673
Abstract
ObjectiveTo compare the spermatogenes response of human chorionic gonadotropin(HCG)combined with human menopausal gonadotropin(HMG)in patients with idiopathic hypogonadotropic hypogonadism(IHH)and congenital combined pituitary hormone deficiency(CCPHD), and to explore related factors.
MethodsClinical data of 90 IHH patients and 61 CCPHD patients from January, 2014 to November, 2018 were retrospectively analyzed. Spermatogenesis was compared between the two groups receiving combined gonadotropin therapy. The patients were then divided into two subgroups: spermatogenesis subgroup and nonspermatogenesis subgroup. Related factors of spermatogenesis after the combined gonadotropin therapy were investigated.
ResultsAfter the combined treatment of HCG/HMG for 3, 6, and 9 months, the patients with CCPHD revealed lower testicular sizes than those with IHH(P=0.004, 0.021 and 0.032, respectively). Compared with IHH patients, CCPHD patients had larger testicular volume increments(P<0.001), higher spermatogenesis rates(P=0.048), and shorter initial time for sperm appearance(P<0.001)after 24-month treatment. Multivariate logistic regression analysis showed that lower total cholesterol(TC)(IHH group: OR=5.508, 95%CI 1.110-27.326, P=0.037; CCPHD group: OR=4.068, 95%CI 1.077-15.371, P=0.039)was an independent risk factor of poorer spermatogenesis in patients with IHH and CCPHD.
ConclusionsThe patients with CCPHD demonstrate a better response to combined gonadotropin treatment than those with IHH. Lower TC is an independent risk factor for poor spermatogenesis of combined HCG/HMG therapy in patients with IHH or CCPHD.
Key words:
Hypogonadotropic hypogonadism; Spermatogenesis; Human chorionic gonadotropin; Human menopausal gonadotropin
Contributor Information
Wang Weijie
Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Shao Mingwei
Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Chen Yuansi
Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Fan Yaya
Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Lian Mengqing
Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Wang Shanshan
Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Wang Xiaotong
Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Qin Guijun
Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
