Original Article
Epidemiological study of respiratory syncytial virus-associated acute lower respiratory tract infection in hospitalized children in Shanghai
Zhuang Shihao, Zeng Mei, Xu Jin, Cai Jiehao, Wang Xiangshi, Su Liyun, Wang Zhonglin
Published 2022-12-15
Cite as Chin J Infect Dis, 2022, 40(12): 735-741. DOI: 10.3760/cma.j.cn311365-20220318-00089
Abstract
ObjectiveTo investigate the epidemiological characteristics of hospitalized children with respiratory syncytial virus (RSV)-associated acute lower respiratory tract infection (ALRTI), and to analyzed the risk factors for severe infection.
MethodsThe epidemiological and clinical data of hospitalized children with ALRTI and positive RSV test from Children′s Hospital of Fudan University from January 2013 to December 2018 were retrospectively analyzed.The hospitalized children from October 2016 to November 2017 were selected by random singular sequence and divided into severe infection group and non-severe infection group. The clinical data of the two groups were compared. Multivariate logistic regression analysis was used to analyze the risk factors of severe RSV-associated ALRTI.
ResultsA total of 34 192 hospitalized children were diagnosed with ALRTI, and 8 113(23.73%) children were positive for respiratory tract viruses, including 4 028(11.78%) children with RSV infection, which was higher than other common respiratory tract viruses. Among the 4 028 RSV-positive children, 2 550(63.31%) were under six months of age, 3 623(89.95%) were under two years of age. The detection rates of RSV in spring, summer, autumn and winter were 6.47%(553/8 551), 2.46%(176/7 161), 12.85%(1 042/8 111) and 21.77%(2 257/10 369), respectively. In 347 hospitalized children with RSV-associated ALRTI, 54 cases were severe cases. Multivariate logistic regression analysis showed that RSV-positive patients complicated with respiratory diseases (Z=3.43), cardiovascular diseases (Z=4.96), non-exclusive breast-feeding (Z=-1.97) and premature birth (Z=-1.98) were independent risk factors for severe RSV-associated ALRTI (all P<0.050).
ConclusionsRSV is the most important and common viral pathogen in hospitalized children with ALRTI in Shanghai, and infants under six months of age are the most susceptible to RSV. RSV patients complicated with respiratory diseases, cardiovascular diseases, non-exclusive breast-feeding and premature birth are more likely to develope severe RSV-associated ALRTI.
Key words:
Respiratory syncytial viruses; Lower respiratory tract infection; Epidemiology; Risk factors; Children
Contributor Information
Zhuang Shihao
Department of Infectious Diseases, Children′s Hospital of Fudan University, Shanghai 201102, China
Zhuang Shihao is working on the Department of Respiratory Medicine, Fujian Maternity and Child Health Hospital, Fuzhou 350000, China
Zeng Mei
Department of Infectious Diseases, Children′s Hospital of Fudan University, Shanghai 201102, China
Xu Jin
Center of Clinical Laboratory, Children′s Hospital of Fudan University, Shanghai 201102, China
Cai Jiehao
Department of Infectious Diseases, Children′s Hospital of Fudan University, Shanghai 201102, China
Wang Xiangshi
Department of Infectious Diseases, Children′s Hospital of Fudan University, Shanghai 201102, China
Su Liyun
Center of Clinical Laboratory, Children′s Hospital of Fudan University, Shanghai 201102, China
Wang Zhonglin
Department of Infectious Diseases, Children′s Hospital of Fudan University, Shanghai 201102, China
