Chen Jie, He Hao, Xu Zhiyong, Jiang Minzhi, Wu Bo, Zhang Junling, He Maozhang, Chen Jingxian, Wang Mingli
Abstract
Dendritic cell (DC) is a kind of professional APC originating from hematopoietic stem cell. Researches have found that DC can efficiently ingest, process and present antigen to other immune cells. Immature DCs have strong migration ability while mature DCs effectively activate naive T cell and induce immune responses timely and moderately. This article reviews the origin, differentiation, characteristics and immunomodulatory capabilities of DC, as well as important current development in the research of DC in tumor treatment and inhibition of inflammatory disease such as atherosclerosis and cytomegalovirus infection.
Key words:
Dendritic cells; Neoplasms; Vaccines; Atherosclerosis; Cytomegalovirus; Activation
Contributor Information
Chen Jie
The Second Clinical Medical College, Anhui Medical University, Hefei 230032, China
He Hao
The Second Clinical Medical College, Anhui Medical University, Hefei 230032, China
Xu Zhiyong
Central and Local Biomedical Engineering Laboratories, Anhui Medical University, Hefei 230032, China
R&
D Department, Wuhu Tianming Biotechnology Co., Ltd., Wuhu 241000, China
Jiang Minzhi
Central and Local Biomedical Engineering Laboratories, Anhui Medical University, Hefei 230032, China
R&
D Department, Wuhu Tianming Biotechnology Co., Ltd., Wuhu 241000, China
Wu Bo
Central and Local Biomedical Engineering Laboratories, Anhui Medical University, Hefei 230032, China
R&
D Department, Wuhu Tianming Biotechnology Co., Ltd., Wuhu 241000, China
Zhang Junling
Central and Local Biomedical Engineering Laboratories, Anhui Medical University, Hefei 230032, China
R&
D Department, Wuhu Tianming Biotechnology Co., Ltd., Wuhu 241000, China
Department of Microbiology, Anhui Medical University, Hefei 230032, China
He Maozhang
Central and Local Biomedical Engineering Laboratories, Anhui Medical University, Hefei 230032, China
R&
D Department, Wuhu Tianming Biotechnology Co., Ltd., Wuhu 241000, China
Department of Microbiology, Anhui Medical University, Hefei 230032, China
Chen Jingxian
Research Center, Guangzhou Kingmed Diagnostics Group Co., Ltd., Guangzhou 510005, China
Wang Mingli
Central and Local Biomedical Engineering Laboratories, Anhui Medical University, Hefei 230032, China
R&
D Department, Wuhu Tianming Biotechnology Co., Ltd., Wuhu 241000, China
Department of Microbiology, Anhui Medical University, Hefei 230032, China
Clinical Medical College, Anhui Medical University, Hefei 230032, China
