Mechanism of the anti-inflammatory effects of interleukin-37 and its function in diseases
He Hao, Chen Jie, Jiang Minzhi, Wu Bo, Xu Zhiyong, Zhang Junling, He Maozhang, Wang Mingli
Abstract
IL-37 is a member of the IL-1 family of cytokines. It consists of five isoforms termed IL-37a—IL-37e. In recent years, it has been found that IL-37 is a dual function cytokine, which exerts broad anti-inflammatory functions both as an intracellular and extracellular cytokine. Intracellularly, it can be translocated into the nucleus of cells with other proteins, consequently reducing the inflammation.IL-37 can also be produced and secreted extracellularly by many cells, and bind to membrane receptors of their own or surrounding cells. This paper summarizes functions of IL-37 and mechanisms of inhibiting inflammation. The latest clinical applications of IL-37 in a wide range of diseases are also discussed, in order to provide new ideas and new targets for clinical anti-inflammatory treatment.
Key words:
Interleukin-37; Anti-inflammatory cytokine; Spinal cord injury; Asthma; Influenza; Renal cell carcinoma; Allergic rhinitis; Lung cancer
Contributor Information
He Hao
The Second Clinical Medical College, Anhui Medical University, Hefei 230032, China
Chen Jie
The Second Clinical Medical College, Anhui Medical University, Hefei 230032, China
Jiang Minzhi
Central and Local Biomedical Engineering Laboratories, Anhui Medical University, Hefei 230032, China
R&
D Department, Wuhu Tianming Biotechnology Co., Ltd., Wuhu 241000, China
Wu Bo
Central and Local Biomedical Engineering Laboratories, Anhui Medical University, Hefei 230032, China
R&
D Department, Wuhu Tianming Biotechnology Co., Ltd., Wuhu 241000, China
Xu Zhiyong
Central and Local Biomedical Engineering Laboratories, Anhui Medical University, Hefei 230032, China
R&
D Department, Wuhu Tianming Biotechnology Co., Ltd., Wuhu 241000, China
Zhang Junling
Central and Local Biomedical Engineering Laboratories, Anhui Medical University, Hefei 230032, China
R&
D Department, Wuhu Tianming Biotechnology Co., Ltd., Wuhu 241000, China
Department of Microbiology, Anhui Medical University, Hefei 230032, China
He Maozhang
Central and Local Biomedical Engineering Laboratories, Anhui Medical University, Hefei 230032, China
R&
D Department, Wuhu Tianming Biotechnology Co., Ltd., Wuhu 241000, China
Department of Microbiology, Anhui Medical University, Hefei 230032, China
Wang Mingli
Central and Local Biomedical Engineering Laboratories, Anhui Medical University, Hefei 230032, China
R&
D Department, Wuhu Tianming Biotechnology Co., Ltd., Wuhu 241000, China
Department of Microbiology, Anhui Medical University, Hefei 230032, China
Clinical Medicine College, Anhui Medical University, Hefei 230032, China
