Original Article
Value of premedication of pronase and simethicone for upper gastrointestinal endoscopy
Aiqin Li, Peng Jin, Lang Yang, Haihong Wang, Xin Wang, Dongliang Yu, Jianqiu Sheng
Published 2016-07-20
Cite as Chin J Dig Endosc, 2016, 33(7): 463-465. DOI: 10.3760/cma.j.issn.1007-5232.2016.07.009
Abstract
ObjectiveTo evaluate the efficacy of premedication of pronase and simethicone before upper gastrointestinal endoscopy.
MethodsA total of 4 690 patients undergoing upper gastrointestinal endoscopy from January 2014 to November 2014 were recruited at gastrointestinal endoscopy center in Beijing Military General Hospital. All patients were randomized into 3 groups. The pronase plus simethicone group(n=1 602) took 40 ml mixed solution of pronase, sodium bicarbonate and simethicone orally 20 minutes before endoscopy. The simethicone group(n=1 548) took 40 ml simethicone orally 20 minutes before endoscopy. And the control group(n=1 540) took 10 ml lidocaine hydrochloride mucilage orally 5 minutes before endoscopy. The visibility during gastroscopy was observed.
ResultsEach patient underwent gastroscopy, and no severe adverse event occurred during the procedure. The visibility of 82.3%(n=1 318) of the pronase plus simethicone group, 67.7%(n=1 048) of the simethicone group and 28.1% patients(n=432) of the control group respectively reached grade A or B. The visibility during gastroscopy in the pronase plus simethicone group was higher than that in the simethicone group(χ2=89.42, P=0.000), while that in the simethicone group was higher than that of the control group(χ2=486.30, P=0.000).
ConclusionPremedication of pronase and simethicone can improve the visibility during gastroscopy.
Key words:
Gastroscopy; Pronase; Simethicone; Visual fields
Contributor Information
Aiqin Li
Department of Gastroenterology, Beijing Military General Hospital, Beijing 100700, China
Peng Jin
Lang Yang
Haihong Wang
Xin Wang
Dongliang Yu
Jianqiu Sheng