Efficacy and safety of endoscopic marking with SPOT for gastrointestinal lesions
Wang Jiaxu, Wu Shanshan, Wang Wenhai, Li Rongxue, Zhao Yu, Zhou Weizhen, Wang Yan, Sun Xiujing, Li Peng, Hao Jianyu, Zhang Shutian
Abstract
ObjectiveTo evaluate the efficacy and safety of SPOT (GI Supply, USA), a new carbon-based permanent marker approved by the Food and Drug Administration (FDA), in the endoscopic marking for gastrointestinal lesions.
MethodsA total of 115 patients with gastrointestinal lesions who underwent endoscopic treatment or surgery in Beijing Friendship Hospital or Beijing Chao-Yang Hospital from April 2019 to November 2019 were enrolled in the study. SPOT was used to mark the lesions, and marking points were found during endoscopic treatment or surgery to calculate the effective marking rate by single-group target value method. Adverse events after marking were recorded, and the changes of blood routine test, liver and kidney functions before and after marking were compared.
ResultsThe effective rate of endoscopic marking with SPOT was 99.13% (114/115). The longest marking time was 57 days. There was no puncture of intestinal wall or injection into abdominal cavity during the marking process. One patient developed mild fever after marking. The incidence of adverse events was 23.48% (27/115), which were all unrelated to the test equipment. There was no significant difference in blood routine tests or liver and kidney functions before and after marking (P>0.05).
ConclusionSPOT produced by GI Supply can effectively mark gastrointestinal lesions without serious adverse events, which meets the requirements of clinical use.
Key words:
Staining and labeling; Orientation; Endoscopy, gastrointestinal; Efficiency; Safety
Contributor Information
Wang Jiaxu
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University
National Clinical Research Center for Digestive Diseases
Beijing Digestive Disease Center
Faculty of Gastroenterology of Capital Medical University
Beijing Key Laboratory for Precancerous Lesions of Digestive Diseases, Beijing 100050, China
Wu Shanshan
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University
National Clinical Research Center for Digestive Diseases
Beijing Digestive Disease Center
Faculty of Gastroenterology of Capital Medical University
Beijing Key Laboratory for Precancerous Lesions of Digestive Diseases, Beijing 100050, China
Wang Wenhai
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University
National Clinical Research Center for Digestive Diseases
Beijing Digestive Disease Center
Faculty of Gastroenterology of Capital Medical University
Beijing Key Laboratory for Precancerous Lesions of Digestive Diseases, Beijing 100050, China
Li Rongxue
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University
National Clinical Research Center for Digestive Diseases
Beijing Digestive Disease Center
Faculty of Gastroenterology of Capital Medical University
Beijing Key Laboratory for Precancerous Lesions of Digestive Diseases, Beijing 100050, China
Zhao Yu
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University
National Clinical Research Center for Digestive Diseases
Beijing Digestive Disease Center
Faculty of Gastroenterology of Capital Medical University
Beijing Key Laboratory for Precancerous Lesions of Digestive Diseases, Beijing 100050, China
Zhou Weizhen
Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
Wang Yan
Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
Sun Xiujing
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University
National Clinical Research Center for Digestive Diseases
Beijing Digestive Disease Center
Faculty of Gastroenterology of Capital Medical University
Beijing Key Laboratory for Precancerous Lesions of Digestive Diseases, Beijing 100050, China
Li Peng
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University
National Clinical Research Center for Digestive Diseases
Beijing Digestive Disease Center
Faculty of Gastroenterology of Capital Medical University
Beijing Key Laboratory for Precancerous Lesions of Digestive Diseases, Beijing 100050, China
Hao Jianyu
Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
Zhang Shutian
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University
National Clinical Research Center for Digestive Diseases
Beijing Digestive Disease Center
Faculty of Gastroenterology of Capital Medical University
Beijing Key Laboratory for Precancerous Lesions of Digestive Diseases, Beijing 100050, China
