Review Article·Basic Research
Research progress on the use of γ-aminobutyric acidergic system against depression
Li Dongxue, Wang Haiyun
Published 2021-03-15
Cite as Int J Anesth Resus, 2021, 42(3): 325-328. DOI: 10.3760/cma.j.cn321761-20190829-00248
Abstract
Depression is caused by the interaction of multiple causes, where depressive patients show significant and persistent emotional changes. γ-aminobutyric acid (GABA) is an important inhibitory neurotransmitter in the mammalian central nervous system, whose abnormal content and function are related to the pathogenesis of depression. Anesthetics exert their effects via GABA receptors. The use of propofol, ketamine and other anesthetics against depression gradually expanded. This article discussed the relationship between depression and dysfunctioned GABA-ergic system and the imbalance of GABA-glutamatergic system, as well as the interaction between GABA and neuroendocrine disorder in patients with depression. On the above discussion, the mechanisms by which intravenous anesthetics (propofol, etomidate) and ketamine, inhalation anesthetics (isoflurane, sevoflurane) and benzodiazepines exert their effects on depression through GABA-ergic system were explored. These findings can provide new targets for the treatment and new thoughts for the compatibility of perioperative anesthetics, so as to relieve the adverse effects of surgical stress on depression.
Key words:
Depression; Anesthetics; Gamma-aminobutyric acid
Contributor Information
Li Dongxue
The Third Central Clinical College of Tianjin Medical University, Department of Anesthesiology, Tianjin Third Central Hospital, Nankai University Affiliated the Third Central Hospital, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Tianjin 300170, China
Wang Haiyun
The Third Central Clinical College of Tianjin Medical University, Department of Anesthesiology, Tianjin Third Central Hospital, Nankai University Affiliated the Third Central Hospital, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Tianjin 300170, China
类镇静催眠药通过GABA能系统影响抑郁症的作用机制，为抑郁症患者提供治疗新靶点和围手术期麻醉药配伍新思路，以减少手术应激对抑郁症的不利影响。
类（benzodiazepines, BZD）麻醉药等均通过γ-氨基丁酸（γ-aminobutyric acid, GABA）能系统发挥作用，而GABA能系统与抑郁症的发展过程密切相关，因此如何通过适宜的麻醉药配伍减轻因手术应激导致的抑郁状态加重是目前亟待解决的问题。本文旨在研究GABA及其受体与抑郁症的关系以及麻醉药通过GABA影响抑郁症的研究进展，为建立适宜抑郁症患者的麻醉策略提供基础。
