Review Article·Critical Care Medicine
Research advances on mitochondrial mechanism of sepsis-induced myocardial injury
Li Yingning, Wang Yuzun, Zheng Weiqiang, Xie Keliang
Published 2022-02-15
Cite as Int J Anesth Resus, 2022, 43(2): 187-190. DOI: 10.3760/cma.j.cn321761-20210914-00484
Abstract
Sepsis is a life-threatening organ dysfunction caused by the host's unbalanced response to infection. Septic cardiomyopathy is a common complication of sepsis. As the main organoid of energy supply for cardiomyocytes, the abnormal structure and dysfunction of mitochondria plays an important role in septic cardiomyopathy. This review aims to summarize the relevant mechanisms of mitochondrial dysfunction which causes myocardial injury in sepsis, including: reactive oxygen species produced and oxidative stress occurred in mitochondria, disorder energy metabolism of mitochondria, imbalanced mitochondrial dynamics, abnormal mitochondrial biosynthesis and autophagy process for providing new ideas to help the clinical treatment of septic myocardial injury.
Key words:
Sepsis; Myocardial injury; Mitochondrial mechanism
Contributor Information
Li Yingning
Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin Research Institute of Anesthesiology, Tianjin 300052, China
Wang Yuzun
Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin Research Institute of Anesthesiology, Tianjin 300052, China
Zheng Weiqiang
Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin Research Institute of Anesthesiology, Tianjin 300052, China
Xie Keliang
Department of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin Research Institute of Anesthesiology, Tianjin 300052, China
Department of Critical Care Medicine, General Hospital of Tianjin Medical University, Tianjin 300052, China
College of Anesthesiology, Translational Research Institute of Intensive Care Medicine, Weifang Medical University, Weifang 261053, China
