Candida albicans is a major mucosal and systemic fungal pathogen in immunocompromisedhosts.Also.it often causes vaginal candidiasis and other mucosal and cutaneous candidiasis in healthy subjects.Invasive candidia infection has a high mortality.Some limimtions have been reported in the efficacy and safetyof convcntional antifungal agents with frequent emergence of resistance.Recently,some new antibody vaccineshave been developed and applied to animal models of and patients with potent anti-candida efficacy.Synergismhas been noticed between anti-candida vaccines and conventional antifungal agents.Though furtherconfirmation is required for the efficacy and safety,anti-candida vaccines have a perfect perspective in clinicalapplication.and is expected to be an adjunctive therapy of candidiasis.