Luliconazole is a novel,optically active,topically applied antifungal imidazole.In vitro and in vivo experimental studies and clinical studies have revealed that luliconazole has a strong wide-spectrum antifungal activity against Dennatophytes spp.,Candida albicans,Malassezia spp.,and some uncommon pathogens including dematiaceous fungi and hyalohyphomycetes.The 50％ minimun inhibitory concentration (MIC50)of luliconazole against Trichophyton rubrum can be as low as 0.00024 μg/ml.In Japan,luliconazole 1％ cream/solution has been approved for the treatment of superficial fungal infections including dermatophytosis,cutaneous candidiasis,and pityriasis versicolor.