Ultraviolet light can interfere with cell signal transduction and induce cells to generate excessive reactive oxygen species (ROS) . Lipids are the major component of biological membranes and the main target of ROS for attack. ROS can react with the polyunsaturated fatty acids of lipid membranes and induce lipid peroxidation. The middle to high level of lipid peroxidation can induce cell apoptosis and programmed necrotic cell death, finally leading to cell damage, promoting the development of a variety of pathological states and accelerating the aging process. Lipid peroxidation can lead to the formation of various highly reactive electrophilic aldehydes, such as malondialdehyde, 4-hydroxy-2-nonenal (4-HNE) and acrolein, which can cause irreversible modification and damage to phospholipids, proteins and DNA. Lipid peroxidation is associated with many skin diseases. Further studies on lipid peroxidation may provide new methods for the prevention and treatment of skin diseases.

Ultraviolet rays; Skin diseases; Reactive oxygen species; Lipid peroxidation; Wounds and injuries