Acne, a kind of inflammatory skin disease involving pilosebaceous units, is likely associated with polygenic inheritance. Its pathogenesis is very complex, and remains unclear currently. Several studies have indicated that single nucleotide polymorphisms (SNPs) in some genes may be related to the susceptibility to acne, such as the L-selectin gene, resistin gene, damage-specific DNA binding protein 2 gene, MYC gene, linked to transforming growth factor pathway-related genes, insulin-like growth factor-1 gene, and so on. This review summarizes research progress in acne-associated gene polymorphisms in 4 aspects, including inflammation-related gene SNPs, androgen receptor-related gene SNPs, transforming growth factor -β pathway-related gene SNPs and insulin-like growth factor-related gene SNPs. To further understand acne-associated gene polymorphisms is of great significance for the research and development of gene-targeting drugs.

Acne vulgaris; Polymorphism, single nucleotide; Inflammation; Receptors, androgen; Transforming growth factors; Insulin-like growth factor Ⅰ