131I Treatment in Thyroid Carcinomas
Predictive value of posttreatment whole body scan for radiation damage to the salivary glands in patients with differentiated thyroid carcinoma
Guiling Wang, Guanghui Liu, Deshun Li, Yaming Li, Yafu Yin, Tingting Han, Qi Wang
Published 2018-03-25
Cite as Chin J Nucl Med Mol Imaging, 2018, 38(3): 164-167. DOI: 10.3760/cma.j.issn.2095-2848.2018.03.004
Abstract
ObjectiveTo evaluate the predictive value of posttreatment whole body scan (Rx-WBS) for radiation damage to the salivary glands in patients with differentiated thyroid carcinoma (DTC).
MethodsFrom April 2015 to June 2015, 24 patients (8 males, 16 females; age: 26-64 years) with DTC, who accepted 131I therapy only one time and underwent Rx-WBS 2-4 d after 131I treatment, were recruited from the First Hospital of China Medical University. All patients had normal salivary glands function on salivary gland scintigraphy (SGS) performed on the day before 131I treatment, and 21 patients underwent SGS again 3 months after 131I treatment. The SGS results and clinical manifestations were used to evaluate the function of salivary glands after 131I therapy. Rx-WBS was analyzed by visual analysis and quantitative analysis (salivary gland to background uptake ratios, SUR). The SUR was compared between patient groups with different function of salivary glands. Mann-Whitney u test was used. Receiver operating characteristic (ROC) curve analysis was used to calculate the sensitivity of SUR for predicting the salivary gland damage.
ResultsThe SUR in dysfunctional parotid glands (n=12) was significantly higher than that in other glands with normal function (n=30; 3.60(2.55, 4.33) vs 2.75(2.33, 3.29); z=-2.005, P<0.05). The SUR was not different between submandibular glands with lower function (n=15) and those with normal function (n=27; z=-0.144, P>0.05). The SUR of parotid glands (n=32) in patients with parotitis was significantly higher than that in others (n=16; 3.16(2.53, 4.01) vs 2.49(2.06, 2.81); z=-3.073, P<0.05). The SUR of submandibular glands (n=28) in patients with sialadenitis was significantly higher than that in others (n=20; 4.43(2.67, 7.61) vs 2.93(1.92, 4.65); z=-2.740, P<0.05). When 2.97 and 3.66 were selected as cutoff values, the sensitivities of SUR for predicting parotitis and sialadenitis were 59%(19/32) and 64%(18/28), respectively.
ConclusionRx-WBS may play a role in predicting radiation damage to the salivary glands.
Key words:
Thyroid neoplasms; Radiotherapy; Iodine radioisotopes; Radiation injuries; Salivary glands; Radionuclide imaging
Contributor Information
Guiling Wang
Department of Nuclear Medicine, the First Hospital of China Medical University, Shenyang 110001, China
Guanghui Liu
Deshun Li
Yaming Li
Yafu Yin
Tingting Han
Qi Wang
