Clinical Investigation
Radiosensitization of sodium glycididazole in esophageal cancer evaluated by 18F-FMISO PET/CT
Dengyun Chen, Huiqin Xu, Hui Wang, Dan Zhang, Wenjing Yu, Xiaoyu Su, Feng Qiao
Published 2019-04-25
Cite as Chin J Nucl Med Mol Imaging, 2019, 39(4): 218-221. DOI: 10.3760/cma.j.issn.2095-2848.2019.04.006
Abstract
ObjectiveTo investigate the feasibility of sodium glycididazole (CMNa) on the radiosensitization of esophageal cancer (EC) by 18F-fluoromisonidazole (FMISO) PET/CT.
MethodsA total of 60 patients with EC from December 2016 to December 2017 were enrolled prospectively and were divided into control group (n=30; 21 males, 9 females; age: (56.6±10.0) years) and experimental group (n=30; 20 males, 10 females; age: (59.3±9.0) years) using completely randomized grouping design. Patients in the control group received radiotherapy alone, and those in the experimental group were treated with conventional radiotherapy and CMNa. All patients underwent 18F-FMISO PET/CT imaging 1 week before and after radiotherapy. The imaging results were visually and semi-quantitatively analyzed. The maximum standardized uptake value (SUVmax), tumor/muscle ratio (T/M), and hypoxia volume (HV) were calculated. Paired t test, two-sample t test and χ2 test were used to analyze the data.
ResultsT/M and HV in the control group before and after radiotherapy were 3.92±0.57 vs 1.66±0.35, (1.84±0.31) vs (1.04±0.15) mm3, respectively; T/M and HV in the experimental group before and after radiotherapy were 4.01±0.68 vs 1.27±0.11, (2.01±0.22) vs (0.90±0.09) mm3, respectively. The primary tumor T/M, HV after radiotherapy in 2 groups were significantly lower than those before radiotherapy (t values: 12.15-24.43, all P<0.05) and the amplitudes of T/M and HV in the experimental group were significantly higher than those in the control group (ΔT/M: 2.77±0.60 vs 2.25±0.49, ΔHV: (1.12±0.18) vs (0.81±0.26) mm3;t values: 3.00 and 1.80, both P<0.05). Meanwhile, the local control rate of EC after 3 months in the experimental group was higher than that in the control group (80.0%(24/30) vs 53.3%(16/30); χ2=4.80, P<0.05).
ConclusionCMNa has the radiosensitizing effect on EC and the 18F-FMISO PET/CT can evaluate the radiosensitization effect.
Key words:
Esophageal neoplasms; Radiotherapy; Radiation-sensitizing agents; Nitroimidazoles; Positron-emission tomography; Tomography, X-ray computed; Misonidazole
Contributor Information
Dengyun Chen
Department of Nuclear Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
Huiqin Xu
Hui Wang
Dan Zhang
Wenjing Yu
Xiaoyu Su
Feng Qiao
