Parkinson's Disease
Disrupted network topology in patients with idiopathic rapid eye movement sleep behavior disorder
Jiang Jiehui, Zhao Deqiang, Zhou Hucheng, Yu Huan, Zuo Chuantao, Wang Jian
Published 2019-06-25
Cite as Chin J Nucl Med Mol Imaging, 2019, 39(6): 325-330. DOI: 10.3760/cma.j.issn.2095-2848.2019.06.002
Abstract
ObjectiveTo explore the topological abnormality of brain metabolic network in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) and compare it with the topology of brain metabolic network in patients with Parkinson′s disease (PD).
MethodsThe 18F-fluorodeoxyglucose (FDG) PET brain images of 19 patients with iRBD diagnosed with polysomnography (PSG) (iRBD group; 15 males, 4 females, average age: 64.9 years), 19 patients with PD (PD group; 12 males, 7 females, average age: 62.2 years) and 19 gender and age-matched healthy controls (HC group; 15 males, 4 females, average age: 63.1 years) in Huashan Hospital from September 2014 to June 2015 were retrospectively analyzed. According to the complex brain network method based on graph theory, the brain metabolic networks of each group was constructed and the network parameters (clustering coefficient, characteristic path length, local efficiency, global efficiency and small-world property, etc) were evaluated quantitatively. The 500 times non-parametric permutation test was used to determine the differences in network parameters between groups.
ResultsThe brain metabolic networks of iRBD group and PD group both had abnormal topological structure, which showed that the characteristic path length (for example, when sparsity=34%, HC vs iRBD vs PD groups: 1.517 vs 1.552 vs 1.561) and local efficiency (for example, when sparsity=30%, HC vs iRBD vs PD groups: 0.802 vs 0.824 vs 0.831) were significantly increased (both P<0.05), the global efficiency (for example, when sparsity=36%, HCvs iRBD vs PD groups: 0.672 vs 0.658 vs 0.656) was significantly decreased (P<0.05). The topology was more aggravated in PD group compared with that in iRBD group.
ConclusionThe graph-based complex brain network analysis can reveal the abnormal topological structure of the brain metabolic network in which iRBD progresses to PD.
Key words:
REM sleep behavior disorder; Parkinson disease; Metabolic networks and pathways; Positron-emission tomography; Deoxyglucose
Contributor Information
Jiang Jiehui
Institute of Biomedical Engineering, Shanghai University, Shanghai 200444, China
Zhao Deqiang
Institute of Biomedical Engineering, Shanghai University, Shanghai 200444, China
Zhou Hucheng
Institute of Biomedical Engineering, Shanghai University, Shanghai 200444, China
Yu Huan
Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200235, China
Zuo Chuantao
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Wang Jian
Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200235, China
