131I Therapy for Thyroid Cancer
Predictive value of stimulated thyroglobulin before the first 131I therapy for children and adolescents with differentiated thyroid carcinoma
Liu Lina, Zhang Xinyue, Liu Bin, Huang Rui, Li Lin
Published 2020-06-25
Cite as Chin J Nucl Med Mol Imaging, 2020, 40(6): 324-328. DOI: 10.3760/cma.j.cn321828-20200219-00054
Abstract
ObjectiveTo investigate the predictive value of stimulated thyroglobulin (sTg) before the first 131I therapy for children and adolescents with differentiated thyroid carcinoma(DTC).
MethodsBetween January 2009 and December 2018, a total of 166 children and adolescents DTC patients (28 males, 138 females; age (16.5±3.0) years) from West China Hospital of Sichuan University were retrospectively analyzed. All patients underwent total thyroidectomy and 131I therapy. According to the treatment response evaluated 6-12 months after 131I therapy, patients were divided into excellent response (ER) group and incomplete response (non-ER) group. Clinical and pathological characteristics of 2 groups were compared using independent-sample t test, Mann-Whitney U test, χ2 test or Fisher′s exact test. The independent predictors for 131I treatment response were analyzed by logistic regression analysis. The cut-off value of sTg for predicting ER was determined by receiver operating characteristic (ROC) curve analysis.
ResultsSixty-one patients achieved ER, while treatment response in 105 patients was non-ER. The level of sTg in non-ER group was significantly higher than that in ER group (52.5(11.8, 259.1) and 3.0(1.5, 9.7) μg/L; z=6.508, P<0.001). In addition, age, risk stratification, N stage, M stage, ratio of invaded lymph nodes and activities of131I administered were also significantly different between those 2 groups (t=2.611, 3.000, z=2.678, χ2=11.432, 16.299; all P<0.05). The level of sTg (odds ratio (OR)=1.156, P=0.002) and administered activity of 131I (OR=0.958, P=0.048) were independent predictors for the responses. ROC curve analysis showed that the best cut-off value of sTg for predicting ER was 16.1 μg/L with the sensitivity of 72.4%(76/105) and the specificity of 96.7%(59/61).
ConclusionssTg has the capability of predicting the response to the first 131I therapy in children and adolescents with DTC. When sTg is lower than 16.1 μg/L, the probability of ER increases.
Key words:
Thyroid neoplasms; Radiotherapy; Iodine radioisotopes; Thyroglobulin; Child; Adolescent; Treatment outcome; Forecasting
Contributor Information
Liu Lina
Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
Zhang Xinyue
Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
Liu Bin
Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
Huang Rui
Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
Li Lin
Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
