Differentiated Thyroid Cancer and Biomarkers
Association between urinary iodine concentration and radioactive iodine therapeutic response in patients with differentiated thyroid cancer
Jiang Yuyan, Meng Zhaowei, Tan Jian, Li Ning, Jia Qiang, Wang Renfei, He Yajing, Zheng Wei
Published 2021-04-25
Cite as Chin J Nucl Med Mol Imaging, 2021, 41(4): 207-211. DOI: 10.3760/cma.j.cn321828-20210201-00022
Abstract
ObjectiveTo explore the impact of urinary iodine concentration (UIC) on response to 131I treatment in differentiated thyroid cancer (DTC) patients with different risk stratifications.
MethodsA total of 181 patients with DTC (75 males, 106 females, age: (44.1±12.5) years), who received the first 131I treatment in Tianjin Medical University General Hospital between January 2018 and February 2019, were retrospectively analyzed. Patients were divided into low- to intermediate-risk and high-risk groups. The treatment response was categorized into excellent response (ER) and non-excellent response (non-ER). Factors being evaluated including age, sex, preablative stimulated thyroglobulin (ps-Tg), UIC, etc. Mann-Whitney U test, χ2 test and logistic regression analysis were used for data analysis.
ResultsThe UIC and ps-Tg in the low- to intermediate-risk group (n=113) was 111.60(55.80, 204.65) μg/L and 2.08(0.63, 4.91) μg/L, respectively. Compared with the ER subgroup ( n=86), non-ER subgroup (n=27) had higher UIC and ps-Tg level (z values: -2.585, -4.511, both P<0.05). In the high-risk group (n=68), UIC was 115.40(61.23, 167.28) μg/L and ps-Tg was 16.65(4.52, 43.45) μg/L. Compared with the ER subgroup ( n=20), non-ER subgroup (n=48) had higher ps-Tg level (z=-4.677, P<0.01), while the UIC was not significantly different between ER and non-ER subgroups (z=-0.013, P>0.05). The multivariate logistic analysis indicated the ps-Tg level was the significant variable for non-ER in low- to intermediate-risk group (odds ratio(OR)=6.157(95% CI: 1.046-36.227); OR=22.965(95% CI: 3.591-146.857), both P<0.05) and high-risk group (OR=9.696 (95% CI: 1.379-68.169), P<0.05); a high UIC could be an indicator of non-ER only in the low- to intermediate-risk group (OR=3.715(95% CI: 1.201-11.488), P<0.05).
ConclusionsThe non-ER is associated with UIC in the low- to intermediate-risk group; however, UIC does not affect the non-ER in the high-risk group. Higher ps-Tg level is associated with non-ER in patients with low- to intermediate-risk and high-risk DTC.
Key words:
Thyroid neoplasms; Radiotherapy; Iodine radioisotopes; Urine; Iodine; Treatment outcome
Contributor Information
Jiang Yuyan
Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China
Meng Zhaowei
Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China
Tan Jian
Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China
Li Ning
Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China
Jia Qiang
Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China
Wang Renfei
Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China
He Yajing
Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China
Zheng Wei
Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China
