Review Article
Advances in the application of nuclear medicine imaging in the diagnosis and treatment of systematic light chain amyloidosis
Wang Xuezhu, Ren Chao, Huang Zhenghai, Shen Kaini, Li Jian, Li Xiao, Wang Yining, Li Fang, Huo Li
Published 2022-04-25
Cite as Chin J Nucl Med Mol Imaging, 2022, 42(4): 243-247. DOI: 10.3760/cma.j.cn321828-20201012-00369
Abstract
Systematic light chain (AL) amyloidosis is the most common forms of amyloidosis, which manifests as multiple organ system involvement, rapid progress, dire prognosis, difficult therapy and high mortality. Many patients may miss the optimal treatment as a result of not being diagnosed timely. Therefore, early diagnosis and assessment of involved extent of AL are clinical focuses. Related clinical studies have demonstrated that nuclear medicine imaging can be non-invasive in detecting amyloid deposits. It can not only early assess the extent and distribution of amyloid deposits in systemic AL amyloidosis, but also offer the indications for risk stratification, treatment response monitoring and prognosis assessment of the patients, especially for positron amyloidosis-specific tracers, which may have great prospects in the future. This review summarizes the application of nuclear medicine imaging in the systematic AL amyloidosis.
Key words:
Amyloidosis; Immunoglobulin light-chains; Positron-emission tomography; Radionuclide imaging; Trends
Contributor Information
Wang Xuezhu
Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences
Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China
Ren Chao
Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences
Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China
Huang Zhenghai
Beijing Atom High Tech Company Limited, Beijing 102413, China
Shen Kaini
Department of Hematology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medicine Sciences, Beijing 100730, China
Li Jian
Department of Hematology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medicine Sciences, Beijing 100730, China
Li Xiao
Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medicine Sciences, Beijing 100730, China
Wang Yining
Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medicine Sciences, Beijing 100730, China
Li Fang
Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences
Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China
Huo Li
Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences
Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China
