PET Dynamic Imaging and Quantification
Added value of 18F-FDG total-body PET/CT dynamic imaging in the diagnosis of liver malignant tumors
Dilibire Adili, Cai Danjie, Cao Yanyan, Shi Hongcheng
Published 2022-12-25
Cite as Chin J Nucl Med Mol Imaging, 2022, 42(12): 724-728. DOI: 10.3760/cma.j.cn321828-20220930-00298
Abstract
ObjectiveTo explore the added value of time-activity curve (TAC) and target-to-background ratio (TBR) obtained by 18F-FDG total-body PET/CT dynamic imaging in the diagnosis of liver malignant tumors.
MethodsFrom December 2019 to October 2021, 109 patients (65 males, 44 females; age (59.3±9.3) years) with hepatocellular carcinoma (HCC; n=27), intrahepatic cholangiocarcinoma (ICC; n=61) and colorectal cancer with liver metastasis (CRLM; n=21) who underwent 60 min 18F-FDG total-body PET/CT dynamic imaging in Zhongshan Hospital, Fudan University were retrospectively enrolled. Dynamic PET/CT images were divided into perfusion-weighted (PW) phase and metabolism-weighted (MW) phase. The arterial phase was defined as the 15 s after the abdominal aorta peak frame at PW. TACs at MW were divided into three types as Graph A, Graph B and Graph C. One-way analysis of variance was used to compare difference of TBR30/60 among groups. ROC curve analysis was used to evaluate diagnostic effectiveness.
ResultsWith hypervascularity as the diagnostic standard of HCC, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 66.7%(18/27), 75.6%(59/78), 48.6%(18/37) and 86.8%(59/68), respectively. With Graph B as the diagnostic standard of HCC, the sensitivity, specificity, PPV and NPV were 44.4%(12/27), 85.4%(70/82), 50.0%(12/24) and 82.4%(70/85), respectively. The TBR30/60 of HCC, ICC and CRLM was 0.38±0.19, 0.49±0.18 and 0.64±0.20 respectively (F=10.89, P<0.001). When the cut-off value of TBR30/60 was 0.43, the AUC of distinguishing HCC from ICC and CRLM was 0.72, with the sensitivity and specificity of 70.5%(55/78) and 65.2%(15/23). When the cut-off value of TBR30/60 was 0.64, the AUC of distinguishing ICC from CRLM was 0.71, with the sensitivity and specificity of 61.9%(13/21) and 82.5%(47/57).
ConclusionTAC graph types and TBR30/60 obtained by total-body PET/CT dynamic imaging display potential value for differentiation between hepatic tumor types.
Key words:
Liver neoplasms; Image interpretation, computer-assisted; Positron-emission tomography; Tomography, X-ray computed; Fluorodeoxyglucose F18
Contributor Information
Dilibire Adili
Department of Nuclear Medicine, Zhongshan Hospital, Fudan University
Nuclear Medicine Institute of Fudan University
Shanghai Institution of Medical Imaging
Cancer Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Cai Danjie
Department of Nuclear Medicine, Zhongshan Hospital, Fudan University
Nuclear Medicine Institute of Fudan University
Shanghai Institution of Medical Imaging
Cancer Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Cao Yanyan
Department of Nuclear Medicine, Zhongshan Hospital, Fudan University
Nuclear Medicine Institute of Fudan University
Shanghai Institution of Medical Imaging
Cancer Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shi Hongcheng
Department of Nuclear Medicine, Zhongshan Hospital, Fudan University
Nuclear Medicine Institute of Fudan University
Shanghai Institution of Medical Imaging
Cancer Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China
