PET Dynamic Imaging and Quantification
Kinetic metrics of 68Ga-FAPI-04 in patients with pancreatic cancer identified by total-body PET/CT dynamic imaging
Chen Ruohua, Yang Xinlan, Huo Yanmiao, Wang Yining, Yu Xiaofeng, Ng Yee Ling, Zheng Chaojie, Zhao Haitao, Li Lianghua, Zhou Yun, Huang Gang, Liu Jianjun
Published 2022-12-25
Cite as Chin J Nucl Med Mol Imaging, 2022, 42(12): 729-733. DOI: 10.3760/cma.j.cn321828-20221028-00323
Abstract
ObjectiveTo investigate the kinetic metrics of 68Ga-fibroblast activation protein inhibitor (FAPI)-04 in pancreatic cancers and normal organs by using total-body PET dynamic imaging.
MethodsFrom December 2020 to December 2021, 68Ga-FAPI-04 total-body PET/CT dynamic imaging were performed on 6 pancreatic cancer patients (3 males, 3 females, median age 55.5 years) in Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University. Images were respectively analyzed. Manual delineations of volume of interests (VOIs) on multiple normal organs and pathological lesions were performed and time-to-activity curves (TACs) were generated. A reversible two-tissue compartment model (2TCM) was fitted for each tissue TAC. Rate constants including K1, k2, k3 and k4, and the total volume of distribution (Vt) were obtained and compared by tissue types. Wilcoxon rank sum test and Spearman correlation analysis were used for data analysis.
ResultsKinetic metrics varied significantly among normal organs and pancreatic cancer lesions (z values: 2.00-1 240.00, all P<0.05). The highestK1 among lesions was observed in primary tumor (0.30 min-1), which was observed in the spleen (1.42 min-1) among normal organs. The highest k2 among lesions was observed in peritoneal metastases (0.24 min-1), which was observed in the spleen (2.59 min-1) among normal organs. Primary tumor showed the highest k3 of 0.17 min-1 among lesions, and the pancreas had the highest k3 of 0.16 min-1 among normal organs. Primary tumor had the highest k4 of 0.03 min-1 among lesions, and the heart, lungs, parotid glands had high k4(0.06 min-1) among normal organs. Vt were higher in pathological lesions compared to normal organs, with the highest in primary tumor (13.78 ml/cm3). There were correlations between Vt in lesions and SUVmean(rs=0.86, P<0.001) or SUVmax (rs=0.77, P<0.001).
ConclusionThe rate constants including K1, k2, k3 and k4, and Vt of 68Ga-FAPI-04 vary among normal organs and lesions.
Key words:
Pancreatic neoplasms; Quinolines; Isotope labeling; Gallium radioisotopes; Pharmacokinetics; Positron-emission tomography; Tomography, X-ray computed
Contributor Information
Chen Ruohua
Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Yang Xinlan
Central Research Institute, United Imaging Healthcare Group Co., Ltd, Shanghai 201807, China
Huo Yanmiao
Department of Biliary-Pancreatic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Wang Yining
Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Yu Xiaofeng
Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Ng Yee Ling
Central Research Institute, United Imaging Healthcare Group Co., Ltd, Shanghai 201807, China
Zheng Chaojie
Central Research Institute, United Imaging Healthcare Group Co., Ltd, Shanghai 201807, China
Zhao Haitao
Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Li Lianghua
Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Zhou Yun
Central Research Institute, United Imaging Healthcare Group Co., Ltd, Shanghai 201807, China
Huang Gang
Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Liu Jianjun
Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
