Clinical Investigations
Imaging study of β-amyloid deposits in preclinical Alzheimer′s disease patients in communities of Shanghai
Wang Mengjie, Xu Shasha, Jiang Donglang, Li Junpeng, Xiao Jianfei, Ren Shuhua, Huang Qi, Guan Yihui, Han Xingmin, Huang Lin, Chen Keliang, Xie Fang, Guo Qihao
Published 2023-01-25
Cite as Chin J Nucl Med Mol Imaging, 2023, 43(1): 20-24. DOI: 10.3760/cma.j.cn321828-20210420-00128
Abstract
ObjectiveTo explore the β-amyloid (Aβ) deposition pattern of subjects with the preclinical Alzheimer′s disease (AD), community-derived amnestic mild cognitive impairment (aMCI) and normal cognition (NC) from communities of Shanghai.
MethodsAccording to the inclusion and exclusion criteria, 273 subjects (104 males, 169 females; age (64.2±7.6) years) were recruited from Shanghai community and memory clinics from December 2018 to July 2020. All subjects underwent MRI, 18F-AV45 PET imaging and neuropsychological scale tests and were grouped into AD, aMCI and NC groups based on clinical diagnosis. Differences in demographic information, the neuropsychological scale tests′ scores and positive rate of Aβ deposition among each group were analyzed by one-way analysis of variance or χ2 test. Aβ deposition patterns of AD and MCI groups were analyzed at voxel level, and the differences of Aβ deposition among different groups were compared.
ResultsAmong 273 patients, the positive rates of Aβ deposition in AD, aMCI and NC groups were 84.4%(38/45), 36.4%(20/55) and 23.1%(40/173), respectively (χ2=58.37, P<0.001). Among AD, aMCI, NC and NC (Aβ-) groups (n=132), the education years of AD group was the lowest ((9.7±4.6) years; F=8.86, P<0.001). In addition, there were significant differences in the scores of several neuropsychological scale tests among AD, aMCI, NC groups and NC (Aβ-) group (F values: 27.68-235.50, all P<0.001). Compared with subjects in NC(Aβ-) group, the Aβ depositions in the aMCI and AD groups were widely distributed in the whole cerebral cortex; and AD group had higher Aβ deposition in bilateral frontal, parietal, temporal, occipital lobe, cingulate gyrus and precuneus than aMCI group.
ConclusionsThe positive rate of Aβ deposition in the preclinical AD population from the Shanghai community is obtained. There are significant different Aβ deposition patterns in subjects at different stages of AD.
Key words:
Alzheimer disease; Cognitive dysfunction; Amyloid; Positron-emission tomography; Ethylene glycols
Contributor Information
Wang Mengjie
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Xu Shasha
Department of Nuclear Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Jiang Donglang
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Li Junpeng
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Xiao Jianfei
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Ren Shuhua
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Huang Qi
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Guan Yihui
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Han Xingmin
Department of Nuclear Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Huang Lin
Department of Geriatrics, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
Chen Keliang
Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200235, China
Xie Fang
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Guo Qihao
Department of Geriatrics, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
