孟宏平; 黄新韵; 陈肖玥; 郭睿; 林晓珠; 王瑾; 李彪; 张淼

doi:10.3760/cma.j.cn321828-20211014-00353

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• 临床研究 •

T₁加权StarVIBE序列对PET/MR图像质量的提升价值

中华核医学与分子影像杂志, 2023,43(3) : 156-160. DOI: 10.3760/cma.j.cn321828-20211014-00353

摘要

目的

探索T₁加权星堆积梯度回波容积内插体部检查(StarVIBE)序列对PET/MR图像质量的提升价值。

方法

回顾性分析2020年4月至2021年4月在上海交通大学医学院附属瑞金医院行¹⁸F－FDG PET/MR检查且PET阳性的患者60例[男42例、女18例，年龄11~86(58±12)岁]。患者均完成StarVIBE序列采集，以梯度回波容积内插体部检查(VIBE)序列为对照，由2位医师采用五分法对2种序列图像进行独立评价，评价内容包括病变显示、病变边界的显示、病变周围的血管显示、与PET图像的融合水平、图像伪影和总体图像质量6个方面。采用Wilcoxon符号秩检验比较2种序列图像质量，采用Kappa检验探讨2位医师图像质量评分的一致性。

结果

StarVIBE序列图像的病变显示[4.0(3.8，4.5)与3.5(3.0，4.0)分]、病变边界的显示[4.0(4.0，4.0)与3.0(3.0，3.5)分]、病变周围的血管显示[5.0(4.0，5.0)与4.0(3.5，4.5)分]、与PET图像的融合水平[5.0(5.0，5.0)与4.5(4.0，5.0)分]、图像伪影[4.5(4.0，5.0)与4.5(4.0，5.0)分]和总体图像质量[5.0(4.0，5.0)与4.0(4.0，4.0)分]均优于VIBE序列(z值：3.77~6.54，均P<0.001)。在颈部和胸部病变周围的血管显示方面，StarVIBE序列优于VIBE序列[颈部：5.0(4.5，5.0)与3.0(2.7，3.5)分；z＝4.49，P<0.001；胸部：4.5(4.3，4.7)与4.0(3.6，4.3)分；z＝3.10，P＝0.002]；在颈部和胸部图像质量方面，StarVIBE序列亦优于VIBE序列[颈部：5.0(4.5，5.0)与4.0(3.7，4.5)分；z＝4.36，P<0.001；胸部：5.0(5.0，5.0)与4.0(4.0，4.5)分；z＝3.02，P＝0.003]；在腹部，StarVIBE序列血管方面的评分高于VIBE序列[4.5(3.5，5.0)与4.0(3.5，4.5)分；z＝2.07，P＝0.038]，两者图像质量基本无差别[4.0(3.7，4.5)与4.0(3.5，4.5)分；z＝0.27，P＝0.785]；盆腔StarVIBE序列图像质量优于VIBE序列[5.0(4.5，5.0)与4.0(4.0，4.5)分；z＝2.12，P＝0.034]。2位医师间图像质量评分一致性程度中等(Kappa＝0.554)。

结论

全身PET/MR显像中StarVIBE序列较VIBE序列可明显提升颈胸部及盆腔病变图像质量。

引用本文: 孟宏平, 黄新韵, 陈肖玥, 等. T₁加权StarVIBE序列对PET/MR图像质量的提升价值 [J] . 中华核医学与分子影像杂志, 2023, 43(3) : 156-160. DOI: 10.3760/cma.j.cn321828-20211014-00353.

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PET/MR探查肿瘤的灵敏度、特异性及准确性高^[1]，具有良好的临床应用前景。常规使用的梯度回波容积内插体部检查(volumetric interpolated body examination, VIBE)序列是1种T₁加权扰相梯度回波序列，可在20 s内完成MRI，提供较高的T₁加权组织分辨率和图像信息，但需受检者配合，且易产生运动伪影^[2]。MR星堆积VIBE(stack－of－stars VIBE, StarVIBE)序列是T₁加权三维(three－dimensional, 3D)梯度回波采集序列，可在自由呼吸状态下进行扫描，不仅可消除呼吸及心脏血管搏动引起的伪影，还能在PET采集过程中达到同时同步精准定位的效果^[3]。已有研究报道了MR采集中StarVIBE序列在颈部、胸部、腹部和盆腔等部位的临床应用^[4,5]，但该序列在PET/MR全身采集中的应用价值的相应研究较少。本研究拟通过MR StarVIBE对PET/MR全身显像中(包括颈部、胸部、腹部、盆腔等)易产生运动伪影的部位进行采集，探讨StarVIBE序列对图像质量的提升价值。

贡献者信息

孟宏平

上海交通大学医学院附属瑞金医院核医学科，上海　200025

黄新韵

上海交通大学医学院附属瑞金医院核医学科，上海　200025

陈肖玥

上海交通大学医学院附属瑞金医院核医学科，上海　200025

郭睿

上海交通大学医学院附属瑞金医院核医学科，上海　200025

林晓珠

上海交通大学医学院附属瑞金医院核医学科，上海　200025

王瑾

上海交通大学医学院附属瑞金医院核医学科，上海　200025

李彪

上海交通大学医学院附属瑞金医院核医学科，上海　200025

张淼

上海交通大学医学院附属瑞金医院核医学科，上海　200025

通信作者

张淼

上海交通大学医学院附属瑞金医院核医学科，上海　200025

Email：zm11648@rjh.com.cn

关键词

图像处理，计算机辅助; 正电子发射断层显像术; 体层摄影术，X线计算机; 氟脱氧葡萄糖F18; 磁共振成像;

作者声明

作者贡献声明

孟宏平：研究实施、论文撰写、统计分析；黄新韵、陈肖玥、郭睿、林晓珠：数据整理分析；王瑾：技术材料支持；李彪、张淼：研究指导、论文修改

利益冲突

所有作者声明无利益冲突

历史

出版日期：2023-03-25

收稿日期：2021-10-14

Clinical Investigation

Added value of T₁-weighted StarVIBE sequence for PET/MR image quality

Meng Hongping, Huang Xinyun, Chen Xiaoyue, Guo Rui, Lin Xiaozhu, Wang Jin, Li Biao, Zhang Miao

Published 2023-03-25

Cite as Chin J Nucl Med Mol Imaging, 2023, 43(3): 156-160. DOI: 10.3760/cma.j.cn321828-20211014-00353

Abstract

Objective

To explore the added value of T₁-weighted stack-of-stars volumetric interpolated body examination (StarVIBE) sequence on PET/MR image quality.

Methods

A retrospective analysis was performed on 60 patients (42 males, 18 females; age 11-86 (58±12) years) who underwent ¹⁸F-FDG PET/MR examination and with positive PET results in Ruijin Hospital, Shanghai Jiao Tong University School of Medicine from April 2020 to April 2021. All patients completed StarVIBE sequence collection, and volumetric interpolated body examination (VIBE) sequence was used as control. StarVIBE and VIBE sequence images were evaluated independently using five-point method by two physicians. The evaluation was carried out from six aspects: lesion display, lesion boundary display, vascular around lesions display, fusion level with PET image, image artifact and overall image quality. Wilcoxon signed rank test was used to compare the image quality of the two sequences, and Kappa test was performed to assess the consistency of the image quality scores between the two physicians.

Results

There were 26 cases with cervical lesions, 14 cases with chest lesions, 7 cases with abdomen lesions and 13 cases with pelvic lesions. The scores of lesion display (4.0(3.8, 4.5) vs 3.5(3.0, 4.0)), lesion boundary display (4.0(4.0, 4.0) vs 3.0(3.0, 3.5)), vascular around lesions display (5.0(4.0, 5.0) vs 4.0(3.5, 4.5)), fusion level with PET image (5.0(5.0, 5.0) vs 4.5(4.0, 5.0)), image artifact (4.5(4.0, 5.0) vs 4.5(4.0, 5.0)) and overall image quality (5.0(4.0, 5.0) vs 4.0(4.0, 4.0)) of StarVIBE sequences were better than those of VIBE sequences (z values: 3.77-6.54, all P<0.001). On the vascular around the lesions display, the scores of StarVIBE were significantly better than those of VIBE sequence in the neck (5.0(4.5, 5.0) vs 3.0(2.7, 3.5); z=4.49, P<0.001) and chest (4.5(4.3, 4.7) vs 4.0(3.6, 4.3); z=3.10, P=0.002). As for image quality, the scores of StarVIBE were also significantly better than those of VIBE in neck (5.0(4.5, 5.0) vs 4.0(3.7, 4.5); z=4.36, P<0.001) and chest (5.0(5.0, 5.0) vs 4.0(4.0, 4.5); z=3.02, P=0.003). In abdominal lesions, the score of StarVIBE was higher than that of VIBE in blood vessels (4.5(3.5, 5.0) vs 4.0(3.5, 4.5); z=2.07, P=0.038), and there was no difference between score of overall image quality (4.0(3.7, 4.5) vs 4.0(3.5, 4.5); z=0.27, P=0.785). The score of overall image quality of pelvic StarVIBE sequence was better than that of VIBE sequence (5.0(4.5, 5.0) vs 4.0(4.0, 4.5); z=2.12, P=0.034). Kappa value of image quality score between two physicians was 0.554, indicating moderate consistency.

Conclusion

In whole-body PET/MR imaging, StarVIBE sequence can significantly improve the image quality of cervical, thoracic and pelvic lesions when comparing with VIBE sequence.

Key words:

Image processing, computer-assisted; Positron-emission tomography; Tomography, X-ray computed; Fluorodeoxyglucose F18; Magnetic resonance imaging

Contributor Information

Meng Hongping