Clinical Investigation
Establishment and clinical verification of brain template for analyzing 11C-CFT PET imaging data
Jiang Chengfeng, Wu Ping, Ge Jingjie, Huang Zhemin, Xiao Jianfei, Yang Yunhao, Li Xiuming, Xu Qian, Zhang Huiwei, Guan Yihui, Zuo Chuantao
Published 2023-04-25
Cite as Chin J Nucl Med Mol Imaging, 2023, 43(4): 216-220. DOI: 10.3760/cma.j.cn321828-20211014-00354
Abstract
ObjectiveTo establish standard spatial brain template and ROIs template of 11C-methyl-N-2β-carbomethoxy-3β-(4-fluorophenyl)tropane (CFT) PET images for automated quantitative analysis of dopamine transporter (DAT) distribution.
MethodsFrom May 2014 to December 2015, 11C-CFT PET and MRI T1 brain images of 16 healthy volunteers (3 males, 13 females; age (63.3±6.9) years) from Huashan Hospital, Fudan University were co-registered and smoothed using statistical parametric mapping(SPM)5 software based on MATLAB to create a standard spatial brain template. The ROIs template was established by ScAnVp procedures. These templates were clinically verified by using 11C-CFT PET images of 37 healthy volunteers (23 males, 14 females; age (61.7±7.1) years), 32 Parkinson′s disease (PD) patients (20 males, 12 females; age (61.1±5.4) years), 10 multiple system atrophy with predominant parkinsonism (MSA-P) patients (7 males, 3 females; age (60.8±7.1) years) and 10 progressive supranuclear palsy (PSP) patients (5 males, 5 females; age (58.4±6.1) years) from Huashan Hospital, Fudan University between January 2014 and March 2019. One-way analysis of variance was used to analyze data.
ResultsBased on the 11C-CFT PET images and MRI T1 images of healthy volunteers, a standard spatial brain template for normalization of 11C-CFT PET images was created. The ROIs template was established including seven regions: bilateral caudate, anterior putamen, posterior putamen (along the long axis) and the occipital cortex. The ROIs template was accurately aligned in each verification group. The normal reference values of semi-quantitative DAT distribution in caudate, anterior putamen and posterior putamen were obtained (1.84±0.13, 2.18±0.16, 1.77±0.11). The semi-quantitative values of 11C-CFT uptake in each ROI in patients were significantly lower than those in healthy volunteers (F values: 49.79-283.83, all P<0.05).
ConclusionThe established brain templates with accurate spatial alignment for 11C-CFT image analysis can provide foundational tools for the application of 11C-CFT PET imaging in clinical practice and scientific research.
Key words:
Tropanes; Isotope labeling; Carbon radioisotopes; Positron-emission tomography; Image processing, computer-assisted; Dopamine plasma membrane transport proteins; Magnetic resonance imaging
Contributor Information
Jiang Chengfeng
Department of Nuclear Medicine, the First People′s Hospital of Kunshan, Suzhou 215300, China
Wu Ping
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Ge Jingjie
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Huang Zhemin
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Xiao Jianfei
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Yang Yunhao
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Li Xiuming
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Xu Qian
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Zhang Huiwei
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Guan Yihui
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Zuo Chuantao
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
