Clinical Investigation
Preliminary application of CT on accessing aortic arch calcification during parathyroid SPECT/CT in patients with renal secondary hyperparathyroidism
Chen Zejun, Xue Qin, Fu Jingjing, Huang Qianhuan, Yu Tanghong, Wu Chaoqun, Wu Xia, Wang Feng
Published 2023-04-25
Cite as Chin J Nucl Med Mol Imaging, 2023, 43(4): 226-229. DOI: 10.3760/cma.j.cn321828-20211025-00369
Abstract
ObjectiveTo access the clinical value and related risk factors of aortic arch calcification (AoAC) in patients with renal secondary hyperparathyroidism (SHPT) on CT during parathyroid SPECT/CT imaging.
MethodsFrom January 2014 to May 2021, 136 renal SHPT patients (70 males, 66 females, age (50.1±11.4) years) who underwent parathyroid 99Tcm-methoxyisobutylisonitrile (MIBI) SPECT/CT in Affiliated Jiangyin Hospital of Nantong University were retrospectively enrolled. AoAC score was estimated with CT(1-5), and patients were divided into none-light AoAC group (AoAC score<3) and moderate-severe AoAC group (AoAC score≥3). Independent-sample t test or Mann-Whitney U test was used to compare differences of various indicators between two groups. Univariate binary logistic regression was used to analyze the influencing factors of AoAC.
ResultsOf 136 renal SHPT patients, 111(81.62%) were AoAC detected by CT. There were 84 patients in none-light AoAC group and 52 patients in moderate-severe AoAC group. The age ((46.7±9.8) vs (55.7±11.6) years; t=-4.84, P<0.001), pulse pressure (52(41, 64) vs 60(51, 70) mmHg (1 mmHg=0.133 kPa); z=-3.27, P=0.001), serum corrected calcium (2.41(2.28, 2.53) vs (2.49±0.22) mmol/L; z=-2.50, P=0.013), serum phosphorus ((1.95±0.39) vs (2.14±0.48) mmol/L; t=-2.54, P=0.012), calcium phosphorus product ((4.68±1.07) vs (5.29±1.10) mmol2/L2;t=-3.21, P=0.013) and parathyroid hormone (PTH) level (106.30(90.15, 127.45) vs 109.90(87.93, 157.63) pmol/L; z=-2.09, P=0.036) between non-light AoAC group and moderate-severe AoAC group were significantly different. Logistic regression analysis showed that serum phosphorus (odds ratio (OR)=7.261, 95% CI: 2.416-21.819, P<0.001), calcium and phosphorus product (OR=1.598, 95% CI: 1.073-2.380, P=0.021) and PTH level (OR=1.018, 95% CI: 1.007-1.029, P=0.001) were independent risk factors of AoAC.
ConclusionsHybrid SPECT/CT can be used for an effective method of evaluating AoAC in patients with renal SHPT. High serum phosphorus, high calcium phosphorus product and high PTH level may be independent risk factors of AoAC.
Key words:
Hyperparathyroidism; Vascular calcification; Aorta, thoracic; Renal insufficiency, chronic; Tomography, X-ray computed
Contributor Information
Chen Zejun
Department of Nuclear Medicine, Affiliated Jiangyin Hospital of Nantong University, Jiangyin People′s Hospital, Wuxi 214400, China
Xue Qin
Department of Ultrasonography, Affiliated Jiangyin Hospital of Nantong University, Jiangyin People′s Hospital, Wuxi 214400, China
Fu Jingjing
Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
Huang Qianhuan
Department of Nuclear Medicine, Affiliated Jiangyin Hospital of Nantong University, Jiangyin People′s Hospital, Wuxi 214400, China
Yu Tanghong
Department of Nephrology, Affiliated Jiangyin Hospital of Nantong University, Jiangyin People′s Hospital, Wuxi 214400, China
Wu Chaoqun
Department of Nuclear Medicine, Affiliated Jiangyin Hospital of Nantong University, Jiangyin People′s Hospital, Wuxi 214400, China
Wu Xia
Department of Nephrology, Affiliated Jiangyin Hospital of Nantong University, Jiangyin People′s Hospital, Wuxi 214400, China
Wang Feng
Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
