Clinical Investigation
Analysis of values and differences of multi-modality registration and normalization methods in 18F-AV45 PET imaging for Alzheimer′s disease
Feng Hongbo, Jiang Yuanfang, Xie Jinghui, Du Xuemei
Published 2023-07-25
Cite as Chin J Nucl Med Mol Imaging, 2023, 43(7): 385-390. DOI: 10.3760/cma.j.cn321828-20211227-00453
Abstract
ObjectiveTo explore values and differences of multi-modality image registration and normalization methods in 18F-AV45 PET quantitative analysis of Alzheimer′s disease (AD).
MethodsTwenty AD patients (10 males, 10 females; age (77.0±5.8) years) and 20 normal controls (NC; 8 males, 12 females; age (75.2±4.8) years) from the AD neuroimaging initiative (ADNI) open database of the National Institute on Aging were analyzed. β-amyloid (Aβ) deposition (positive/negative) was assessed by visual analysis. The SUV ratio (SUVr) in each brain region and individual average SUVr were calculated using template normalization method (M1), normalization after registration with 18F-FDG PET or MRI image (M2 or M3) respectively with the cerebellum as the reference area. The intra-class correlation coefficient (ICC) was used to complete the reliability between methods, and independent-sample t test and one-way repeated measures analysis of variance were used to compare the differences of quantitative indexes between different groups and different methods. ROC curve analysis was used to compare the diagnostic efficacy in distinguishing AD and NC, Aβ positive and negative cases.
ResultsThere were 15 and 6 patients with positive Aβ deposition in AD group and in NC group respectively by visual analysis. The SUVrs of three methods were with good consistency (ICC=0.82, P<0.001), and the differences among individual average SUVrs (1.29±0.17, 1.36±0.23, 1.45±0.24) were significant (F=68.78, P<0.001). There were significant differences between AD group (1.39±0.17, 1.48±0.24, 1.58±0.25) and NC group (1.20±0.10, 1.24±0.15, 1.33±0.16; t values: 3.55-4.33, all P<0.05), Aβ positive group (1.39±0.16, 1.50±0.21, 1.59±0.23) and negative group (1.19±0.11, 1.21±0.14, 1.31±0.15; t values: 4.58, 5.11, 4.41, all P<0.001), and the individual average SUVr of M3 was higher (both P<0.001). The AUCs of distinguishing Aβ positive and negative deposition of M1-M3 were 0.86, 0.88, 0.84 and the thresholds of SUVrs were 1.29, 1.37, 1.52, respectively.
ConclusionThe three multi-modality registration and normalization methods are reliable methods for quantitation of 18F-AV45 PET imaging with certain differences, and should be selected carefully based on data conditions in practice.
Key words:
Alzheimer disease; Amyloid; Image processing, computer-assisted; Positron-emission tomography
Contributor Information
Feng Hongbo
Department of Nuclear Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
Jiang Yuanfang
Department of Nuclear Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
Xie Jinghui
Department of Nuclear Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
Du Xuemei
Department of Nuclear Medicine, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
