To compare the effects of glutathione and tiopronin in chemo-induced liver injury respectively.

122 patients with gastrointestinal cancer who were diagnosed with chemo-induced liver injure were chosen.According to random number table, they were divided into treatment group(63 cases) and control group(59 cases). The control group were given glutathione 1.8g/d intravenously, while the treatment group were given tiopronin 0.2g/d.Both treatments lasted a week.Liver function indexes before/after the treatment were observed respectively, as well as the symptoms of every patient.The adverse drug reactions of both treatments were also observed.

The remission ratio of the treatment group and the control group was 90.48% and 81.35%, respectively, the difference of the two groups was statistically significant(χ²=7.65, P<0.05). The liver function indexes of the two groups before the treatment had no significant differences(t=0.75, 1.23, 0.97, 0.95, all P>0.05); after both treatment the indexes were significantly improved, and ALT, TBIL, AST and ALP between the two groups were significantly different(t=4.67, 6.13, 4.76, 6.90, all P<0.05). The adverse drug reactions of the two groups had no significant difference(χ²=0.42, P>0.05), and no severe adverse drug reactions were observed in our research.

Tiopronin is more effective in treating chemo-induced liver injure caused by capetcitabine/5-FU and oxaliplatin, when compared with glutathione.And no severe adverse drug reaction were observed in our research.

Hepatic insufficiency; Antineoplastic combined chemotherapy protocols; Tiopronin; Glutathione