Original Article
Efficacy and security of triple aerosol inhalation of pulmicort respules, ventolin and ipratropine in treatment of severe acute asthma exacerbations
Peifang Wang
Published 2017-06-01
Cite as Chin J Prim Med Pharm, 2017, 24(11): 1719-1723. DOI: 10.3760/cma.j.issn.1008-6706.2017.11.032
Abstract
ObjectiveTo investigate the clinical efficacy and safety of intravenous inhalation of pumicillin, ventolin and ipratropine in the treatment of severe acute asthma exacerbations in adults.
Methods78 adult patients with severe asthma were randomly divided into research group and control group by the method of random number table.The patients in the control group received routine treatment, it was intravenous infusion of methylprednisolone.On the basis of the above, the research group received intravenous inhalation of pumicil. The clinical efficacy, methylprednisolone use and use of time, asthma symptoms score, the disappearance of asthma symptoms and the incidence of adverse reactions of the two groups were observed and compared.
ResultsThe effective rate of the research group was 97.44% (38/39), which was higher than 82.05% (32/39) of the control group (χ2=5.014, P<0.05). The amount and time of use of methylprednisolone in the study group were lower than those in the control group(t=-6.410, -3.993, all P<0.05). After treatment, the daily and nocturnal asthma scores of the two groups were lower than those before treatment (all P<0.05). After treatment, daily and nocturnal asthma scores in the same day of the research group were lower than the control group (all P<0.05). The time of disappearance of shortness of breath, chest tightness, wheezing and intrapulmonary bowel sounds were shorter in the research group than those in the control group(t=-4.709, -2.929, -5.253, -4.082, all P<0.05). The incidence of adverse reactions in the study group was 12.8%(5/39), which in the control group was 15.4%(6/39), the differences was no statistically significant(χ2=0.106, P>0.05).
ConclusionOn the basis of intravenous medication, combined with pumicillin, ventolin and ipratropine triple inhalation in the treatment of severe asthma patients, can reduce the intravenous use of methylprednisolone, it was effective in patients with asthma symptoms, the clinical efficacy is significant, the clinical value is higher, it is worthy of promotion and application.
Key words:
Asthma; Pumicillin; Ventolin; Ipratropine
Contributor Information
Peifang Wang
Department of Respiratory Medicine, the People's Hospital of Cixi, Cixi, Zhejiang 315300, China
