Original Article
Expression and clinical significance of CK5/6, DSG3, P40, TTF-1, CK7, NapsinA in small biopsy specimens of non-small cell lung cancer
Zhang Xindong, Ma Jing, Wang Xiangge, Zhao Tiantian
Published 2020-01-15
Cite as Chin J Prim Med Pharm, 2020, 27(2): 218-221. DOI: 10.3760/cma.j.issn.1008-6706.2020.02.021
Abstract
ObjectiveTo detect the expression and the differential significance of CK5/6, DSG3, P40, TTF-1, CK7, NapsinA in small biopsy specimens of non-small cell lung cancer (NSCLC), squamous cell carcinoma (SCC) and adenocarcinoma (AC).
MethodsImmunohistochemical SP method was used to detect the expressions of CK5/6, DSG3, P40, TTF-1, CK7 and NapsinA in 120 small biopsy specimens of NSCLC hospitalized in the Central People's Hospital of Tengzhou from January 2016 to December 2017, and the results were analyzed combined with the clinical characteristics of NSCLC.
ResultsThe positive expression rates of CK5/6, DSG3 and P40 in lung SCC were 100.0%(56/56), 89.3%(50/56) and 96.4%(54/56), respectively, with specificity of 90.6%, 100.0% and 100.0%, respectively.The positive expression rates of NapsinA, TTF-1 and CK7 in lung AC were 81.3%(52/64), 90.6%(58/64) and 93.8%(60/64), respectively, with specificity of 100.0%, 92.9% and 96.4%, respectively.The positive expression rates of CK5/6, DSG3, P40 in SCC had statistically significant differences compared with those in AC (all P<0.05), and the expression of TTF-1, CK7 and NapsinA in AC had statistically significant differences compared with those in SCC (allP<0.05).
ConclusionCK5/6, DSG3, P40, TTF-1, CK7 and NapsinA are of great significance in the differential diagnosis of SCC and AC in small biopsy specimens of NSCLC.
Key words:
Carcinorna, non-small-cell lung; CK5/6; DSG3; P40; TTF-1; CK7; NapsinA; Biopsy; Immunohistochemistry
Contributor Information
Zhang Xindong
Department of Pathology, the Central People's Hospital of Tengzhou, Tengzhou, Shandong 277500, China
Ma Jing
Department of Pathology, the Central People's Hospital of Tengzhou, Tengzhou, Shandong 277500, China
Wang Xiangge
Department of Pathology, the Central People's Hospital of Tengzhou, Tengzhou, Shandong 277500, China
Zhao Tiantian
Department of Pathology, the Central People's Hospital of Tengzhou, Tengzhou, Shandong 277500, China
