Therapeutic effect of Weichangning granule combined with compound Lactobacillus acidophilus tablet in the treatment of diarrhea type irritable bowel syndrome and its effect on inflammatory factors, gastrointestinal hormones and intestinal mucosal barrier
Jiang Jianhua, Jiang Jing, Feng Yonghang, Gao Chuan
Published 2020-08-15
Cite as Chin J Prim Med Pharm, 2020, 27(16): 1952-1956. DOI: 10.3760/cma.j.issn.1008-6706.2020.16.008
Abstract
ObjectiveTo investigate the therapeutic effect of Weichangning granule combined with compound Lactobacillus acidophilus tablet on diarrhea type irritable bowel syndrome and its effect on inflammatory factors, gastrointestinal hormones and intestinal mucosal barrier.
MethodsFrom January 2017 to December 2019, 80 patients with diarrhea type irritable bowel syndrome admitted in the First People's Hospital of Fuyang District were selected, and they were divided into observation group and control group according to the random digital table method, with 40 cases in each group.The control group was treated with relapsed Lactobacillus acidophilus tablets, and the observation group was treated with Weichangning granules on the basis of the control group.The course of treatment in both two groups was 2 weeks.The changes of inflammatory factors, gastrointestinal hormones and intestinal mucosal barrier were compared before and after treatment.
ResultsThe total effective rate of the observation group[92.50%(37/40)] was higher than that of the control group[70.00%(28/40)], the difference was significant (χ2=6.646, P<0.05). The levels of TNF-α[(36.15±10.12)ng/L], IL-1β[(0.43±0.08)μg/L] and IL-6[(12.18±3.06)ng/L] in the observation group were lower than those in the control group[(54.36±15.73)ng/L, (0.79±0.12)μg/L and (18.53±2.19)ng/L](t=6.157, 15.787, 10.673, all P<0.05). The serum levels of SS[(28.91±11.02)μg/L] and VIP[(185.46±17.34)ng/L] in the observation group were lower than those in the control group[(45.63±12.54)μg/L and (235.12±18.29)ng/L](t=6.334, 12.462, all P<0.05). The levels of DAO[(1.05±0.19)U/L], endotoxin[(0.62±0.19)U/L] and D-lactate[(38.97±6.39)mg/L] in the observation group were lower than those in the control group[(1.53±0.28)U/L, (1.16±0.23)U/L and (49.81±4.25)mg/L](t=8.972, 11.448, 8.934, all P<0.05).
ConclusionWeichangning granule combined with compound Lactobacillus acidophilus tablet has obviously curative effect on diarrhea type irritable bowel syndrome, which can reduce inflammatory reaction, improve gastrointestinal hormone and intestinal mucosal barrier function.
Key words:
Irritable bowel syndrome; Diarrhea; Weichangning granules; Compound Lactobacillus acidophilus tablets; Inflammation mediators; Gastrointestinal hormones
Contributor Information
Jiang Jianhua
Endoscopy Center, the First People's Hospital of Fuyang District, Hangzhou, Zhejiang 311400, China
Jiang Jing
Endoscopy Center, the First People's Hospital of Fuyang District, Hangzhou, Zhejiang 311400, China
Feng Yonghang
Endoscopy Center, the First People's Hospital of Fuyang District, Hangzhou, Zhejiang 311400, China
Gao Chuan
Endoscopy Center, the First People's Hospital of Fuyang District, Hangzhou, Zhejiang 311400, China
