To observe the clinical effect and safety of lauryl alcohol injection under the guidance of ultrasound in the treatment of thyroid cyst.

From February 2017 to February 2019, 148 patients with thyroid cyst who had been treated in the First People's Hospital of Huzhou were divided into study group and control group according to the random number table method, with 74 patients in each group.The patients in the study group were treated with ultrasound-guided percutaneous injection of lauryl alcohol, while the patients in the control group were treated with ultrasound-guided percutaneous injection of anhydrous ethanol.The changes of serum free triiodothyronine(FT₃), free tetraiodothyronine(FT₄) and thyroid-stimulating hormone(TSH) were compared before treatment and after treatment for 6 months.The curative effect was evaluated and the adverse reactions were observed after treatment.

There were no statistically significant differences in the serum TSH, FT₃ and FT₄ between the two groups before and after treatment(t=-0.514~0.624, P=0.513~0.852). The overall effective rate in the study group(94.59%) was significantly higher than that in the control group(82.43%)(χ²=5.382, P=0.020). The overall incidence of adverse reactions in the study group(12.16%) was significantly lower than that in the control group(31.08%)(χ²=7.815, P=0.005).

Ultrasound-guided injection of lauryl alcohol and anhydrous ethanol did not affect the thyroid function of patients with thyroid cysts, while ultrasound-guided injection of lauryl alcohol is conducive to improve the efficacy of thyroid cysts, and the safety is higher, which is worthy of clinical application.

Goiter, nodular; Ultrasonography; Injections, intralesional; Sclerotherapy; Lauryl alcohol; Anhydrous ethanol