Systematic Review
Effects of statin therapy on the outcome of acute ischemic stroke: a meta-analysis
Zhaoxia Wei, Suyue Pan, Feng Qi, Ke Yu, Zuyou Liu
Published 2016-05-20
Cite as Chin J Behav Med & Brain Sci, 2016, 25(5): 476-480. DOI: 10.3760/cma.j.issn.1674-6554.2016.05.019
Abstract
ObjectiveTo analyze quantitatively the safety and efficacy of statin therapy in acute phrase for acute ischemic stroke with the method of meta-analysis.
MethodsWe performed a systematic literature search including the Cochrane Library, MEDLINE and EMBASE for published trials about statin therapy and the outcomes of acute ischemic stroke.Then we performed a meta-analysis with included studies to investigate the association between statin therapy and clinical outcome and mortality.All of the data were pooled and meta-analyzed by Cochrane Collaboration RevMan 5.3 meta-analysis software.Statistical heterogeneity between studies was evaluated by the chi-square and I-square tests.Forest plots were used to summarize study data and Egger tests were used to assess publication bias.
ResultsA total of 27 studies including 52 034 patients, comprising 19 212 statin users and 32 822 non-statin users met the inclusion criteria, 4 studies were randomized controlled trials (RCTs), and 23 were observational trials (OTs). Both pre-or post-stroke statin use was associated with reduced mortality.Statin use is associated with favorable functional outcome at hospital discharge and on the ninetieth day regardless of initiation time for pre-stroke group and post-stroke group.The results from observational trials were consistent with randomized controlled trials.There was no evidence of publication bias for all comparisons by Egger tests.
ConclusionsStatin therapy before or after AIS is safe and effective.
Key words:
Statin therapy; Acute ischemic stroke (AIS); Modified rankin scale(mRS); Meta-analysis
Contributor Information
Zhaoxia Wei
Department of Neurology, the Third Affiliated Hospital of Guangzhou Medical University, Guangdong 510170, China
Suyue Pan
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangdong 510515, China
Feng Qi
Department of Neurology, the Third Affiliated Hospital of Guangzhou Medical University, Guangdong 510170, China
Ke Yu
Department of Neurology, the Third Affiliated Hospital of Guangzhou Medical University, Guangdong 510170, China
Zuyou Liu
Department of Neurology, the Third Affiliated Hospital of Guangzhou Medical University, Guangdong 510170, China
