Clinical Researches
Analysis of clinical features and its influencing factors of depression patients with and without psychotic symptoms
Xiuying Li, Hong Chen, Jian Xin
Published 2016-08-20
Cite as Chin J Behav Med & Brain Sci, 2016, 25(8): 732-735. DOI: 10.3760/cma.j.issn.1674-6554.2016.08.013
Abstract
ObjectiveTo analyze the clinical features and its influencing factors of depression patients with and without psychotic symptoms.
MethodsAccording to the presence of psychotic symptoms, 374 patients with major depression were divided into psychotic major depression (PMD group, 79 case) and nonpsychotic major depression (NMD group, 268 case). All patients completed social demographic questionnaire (including gender, age, marital status, educational level, family history, positive family history of psychiatric disorder, disease onset age, frequency of attack, times of hospitalization, etc.) and Hamilton's depression scale (HAMD-24).
ResultsPositive family history(PMD group 47/79, NMD group 104/268, P<0.01), psychiatric disorder positive family history(PMD group 19/79, NMD group 26/268, P<0.01) and times of hospitalization(PMD group(2.52±1.29), NMD group(1.39±1.31), P<0.01) in the PMD group were significantly higher than the NMD group.HAMD total scores(PMD total score(47.85±8.69), NMD total score(43.44±8.51), P<0.01), the factor score of anxiety/somatization(PMD group(11.40±3.28), NMD group(9.19±3.54), P<0.01) and cognitive impairment(PMD group(12.24±3.77), NMD group(9.45±3.68), P<0.01) in the PMD group were significantly higher than the NMD group.Disease onset age(PMD group(30.09±5.17), NMD group(35.95±9.06), P<0.01), the course of the disease(PMD group(1.58±0.76), NMD group(3.02±2.87), P<0.01), the factor score of day and night change(PMD group(0.76±0.46), NMD group(1.01±0.51), P<0.01) in PMD group were significantly lower than the NMD. Logistic regression analysis showed the major depression with positive family history of mental disorders(β=3.278), attack in early age(β=-2.524), seriously cognitive dysfunction in patients(β=3.836) may indicate the psychotic symptoms(P<0.05).
ConclusionPMD patients more positive family history, psychiatric disorder positive family history, likely to be hospitalization, severe symptoms and attack in early age compared with NMD. With positive family history of mental disorders, attack in early age, seriously cognitive dysfunction in patients with major depression may indicate the psychotic symptoms.
Key words:
Depression; Psychotic symptoms; Clinical features
Contributor Information
Xiuying Li
Psychiatry Hospital of Jining City
Shandong Ankang Hospital
Affiliated Second Hospital to Jining Medical University, Jining 272051, China
Hong Chen
Psychiatry Hospital of Jining City
Shandong Ankang Hospital
Affiliated Second Hospital to Jining Medical University, Jining 272051, China
Jian Xin
Psychiatry Hospital of Jining City
Shandong Ankang Hospital
Affiliated Second Hospital to Jining Medical University, Jining 272051, China
